Results 11 to 20 of about 272 (113)

Safety and Efficacy of MLC601 in Iranian Patients after Stroke: A Double-Blind, Placebo-Controlled Clinical Trial [PDF]

Stroke Research and Treatment, 2011
Objective. To investigate the safety and efficacy of MLC601 (NeuroAid) as a traditional Chinese medicine on motor recovery after ischemic stroke. Methods.
A. A. Harandi, R. Abolfazli, A. Hatemian, K. Ghragozlee, M. Ghaffar-Pour, M. Karimi, S. Shahbegi, H. Pakdaman, M. Tabasi, A. L. Tabatabae, A. Nourian   +10 more
doaj   +4 more sources

Cost-effectiveness of MLC601 in post-stroke functional recovery compared with placebo - the CHIMES & CHIMES-E studies [PDF]

BMC Health Services Research
Background Despite progress in stroke therapy (e.g., revascularisation interventions by thrombolysis and/or thrombectomy, organised stroke care), many stroke survivors will have impairment of neurological function.
Christopher Li Hsian Chen, Jia Hui Chai, Yogesh Mahadev Pokharkar, Narayanaswamy Venketasubramanian   +3 more
doaj   +4 more sources

Safety and Use of MLC601/MLC901 (NeuroAiD^TM) in Primary Intracerebral Hemorrhage: A Cohort Study from the NeuroAiD Safe Treatment Registry [PDF]

Brain Sciences, 2020
Background: MLC601/MLC901 (NeuroAiD™) is a combination of natural products shown to be safe and to aid neurological recovery after brain injuries, especially ischemic stroke. Few studies have investigated NeuroAiD in primary intracerebral hemorrhage (ICH)
Ramesh Kumar, Azizi Abu Bakar, Jegan Thanabalan, Sanmugarajah Paramasvaran, Charng Jeng Toh, Ainul Jaffar, Farizal Fadzil, Palaniandy Kamalanathan, Bee Hong Soon, Narayanaswamy Venketasubramanian   +9 more
doaj   +5 more sources

Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies. [PDF]

Cerebrovasc Dis, 2018
Background and Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional ...
Suwanwela NC, Chen CLH, Lee CF, Young SH, Tay SS, Umapathi T, Lao AY, Gan HH, Baroque Ii AC, Navarro JC, Chang HM, Advincula JM, Muengtaweepongsa S, Chan BPL, Chua CL, Wijekoon N, de Silva HA, Hiyadan JHB, Wong KSL, Poungvarin N, Eow GB, Venketasubramanian N, CHIMES-E Study Investigators.   +22 more
europepmc   +5 more sources

Effectiveness and Safety of MLC601 in the Treatment of Mild to Moderate Alzheimer's Disease: A Multicenter, Randomized Controlled Trial [PDF]

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background: MLC601 is a possible modulator of amyloid precursor protein processing, and in a clinical trial study MLC601 showed some effectiveness in cognitive function in Alzheimer's disease (AD) patients.
Hossein Pakdaman, Ali Amini Harandi, Hamidreza Hatamian, Mojgan Tabatabae, Hosein Delavar Kasmaei, Amirhossein Ghassemi, Koroush Gharagozli, Farzad Ashrafi, Pardis Emami Naeini, Mehrnaz Tavakolian, Darush Shahin   +10 more
doaj   +5 more sources

Efficacy and Safety of MLC601 in Patients with Mild to Moderate Alzheimer Disease: An Extension 4-Year Follow-Up Study [PDF]

Dementia and Geriatric Cognitive Disorders Extra, 2018
Background and Aim: Alzheimer disease (AD) is the most common cause of dementia. Currently, there is no disease-modifying therapy for AD. We aimed to evaluate the long-term efficacy and safety of MLC601 in the treatment of AD. Methods: In this open-label
Hossein Pakdaman, Koroush Gharagozli, Mehdi Abbasi, Ali Sobhanian, Ali Bakhshandehpour, Farzad Ashrafi, Mitra Khalilzad, Ali Amini Harandi   +7 more
doaj   +5 more sources

Efficacy of MLC601 on functional recovery after stroke: A systematic review and meta-analysis of randomized controlled trials [PDF]

Brain Injury, 2016
Background and purpose: Traditional Chinese medicine (TCM) MLC601 has shown promising results on functional recovery of patients after stroke. This study aimed to evaluate the pooled effect of its efficacy. Methods: Systematic review and meta-analysis of
Eduardo González-Fraile, Javier Ballesteros   +1 more
exaly   +5 more sources

The Relationship between Ischemic Stroke Patients with and without Retroflex Tongue: A Retrospective Study [PDF]

Evidence-Based Complementary and Alternative Medicine, Volume 2017, Issue 1, 2017., 2017
Background. Patients suffering from stroke exhibit different levels of capability in retroflex tongues, in our clinical observation. This study aims to derive the association of tongue retroflexibility with the degree of severity for stroke patients ...
John Y. Chiang, Lun-Chien Lo, Mu-Chien Sun, Po-Chi Hsu, Yu-Liang Chen, Yung-Sheng Huang   +5 more
core   +3 more sources

NEURoaid II (MLC901) in cognitively Impaired not demenTEd patientS (NEURITES): A pilot double blind, placebo-controlled randomized trial. [PDF]

Alzheimers Dement (N Y), 2021
Abstract Objective To investigate the efficacy and safety of MLC901 in vascular cognitive impairment no dementia (VCIND) patients. Design This was a multi‐center, double‐blind, randomized, placebo‐controlled pilot study. Setting and participant VCIND patients from hospitals in Singapore (67), Vietnam (19), and the Philippines (17) were recruited and ...
Chen CLH, Nguyen TH, Marasigan S, Lee CF, Lu Q, Kandiah N, de Silva D, Chong E, Venketasubramanian N.   +8 more
europepmc   +2 more sources

Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review [PDF]

Stroke Research and Treatment, Volume 2016, Issue 1, 2016., 2016
Background. Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power.
Aimie Nunn, Philip M. Bath, Laura J. Gray, David S. Liebeskind   +3 more
core   +2 more sources