Results 21 to 30 of about 252 (105)

Translational Medicine in Acute Ischemic Stroke and Traumatic Brain Injury—NeuroAiD Trials, from Traditional Beliefs to Evidence-Based Therapy [PDF]

Biomolecules
Acute ischemic stroke (AIS) and traumatic brain injury (TBI) are two severe neurological events, both being major causes of death and prolonged impairment.
Narayanaswamy Venketasubramanian, Tseng Tsai Yeo, Christopher Li Hsian Chen   +2 more
doaj   +2 more sources

A scoping review of stroke services within the Philippines. [PDF]

BMC Health Serv Res
Background: Stroke is a leading cause of mortality and disability. In higher-income countries, mortality and disability have been reduced with advances in stroke care and early access to rehabilitation services.
Logan A, Faeldon L, Kent B, Ong A, Marsden J.   +4 more
europepmc   +3 more sources

Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review. [PDF]

Drug Des Devel Ther
Yisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence ...
Ren Y, Chen G, Hong Y, Wang Q, Lan B, Huang Z.   +5 more
europepmc   +3 more sources

Efficacy of MLC601 on functional recovery after stroke: A systematic review and meta-analysis of randomized controlled trials [PDF]

Brain Injury, 2016
Background and purpose: Traditional Chinese medicine (TCM) MLC601 has shown promising results on functional recovery of patients after stroke. This study aimed to evaluate the pooled effect of its efficacy. Methods: Systematic review and meta-analysis of
Eduardo González-Fraile (1910044), Javier Ballesteros (533070), Manuel Martín-Carrasco (1910041)   +2 more
core   +4 more sources

NEURoaid II (MLC901) in cognitively Impaired not demenTEd patientS (NEURITES): A pilot double blind, placebo-controlled randomized trial. [PDF]

Alzheimers Dement (N Y), 2021
Abstract Objective To investigate the efficacy and safety of MLC901 in vascular cognitive impairment no dementia (VCIND) patients. Design This was a multi‐center, double‐blind, randomized, placebo‐controlled pilot study. Setting and participant VCIND patients from hospitals in Singapore (67), Vietnam (19), and the Philippines (17) were recruited and ...
Chen CLH, Nguyen TH, Marasigan S, Lee CF, Lu Q, Kandiah N, de Silva D, Chong E, Venketasubramanian N.   +8 more
europepmc   +2 more sources

Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review [PDF]

Stroke Research and Treatment, Volume 2016, Issue 1, 2016., 2016
Background. Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power.
Aimie Nunn, Philip M. Bath, Laura J. Gray, David S. Liebeskind   +3 more
core   +2 more sources

Safety Profile of MLC601 (Neuroaid®) in Acute Ischemic Stroke Patients: A Singaporean Substudy of the Chinese Medicine Neuroaid Efficacy on Stroke Recovery Study

Cerebrovascular Diseases, 2010
<i>Background:</i> Previous clinical trials have shown that Neuroaid® (MLC601), a traditional Chinese medicine, shows good tolerability and superiority over another traditional Chinese medicine in terms of neurological disability and ...
Angeline Koh, Bernard P.L. Chan, Christopher Chen, Hui Meng Chang, N. Venketasubramanian, Rajinder Singh, Sherry H.Y. Young, Yudong Zhao   +7 more
core   +3 more sources

NeuroAiD® (MLC601) and Amyloid Precursor Protein Processing [PDF]

Cerebrovascular Diseases, 2013
<b><i>Background:</i></b> Amyloid precursor protein (APP) undergoes cleavage under physiological conditions, predominantly by α- and &#947;-secretases, to form the nonpathogenic sAPPα and p3 fragments. By contrast, amyloid-beta (Aβ) is produced via proteolytic cleavage by β- and &#947;-secretases. In Alzheimer's disease (
Lim, YA, Murray, LA, Lai, MKP, Chen, C
openaire   +2 more sources

Traditional Chinese medicines in the management of cardiovascular diseases:A comprehensive systematic review [PDF]

, 2016
AIMS: The aim was to perform a systematic review of the efficacy of traditional Chinese medicines (TCM) in cardiovascular disease. METHODS: Electronic databases were searched up to 11 November 2015 for all randomized‐controlled trials evaluating the ...
Ferro, Albert, Layne, Kerry
core   +4 more sources

Effects of MLC601 on Early Vascular Events in Patients After Stroke [PDF]

Stroke, 2013
Background and Purpose— Early vascular events are an important cause of morbidity and mortality in the first 3 months after a stroke. We aimed to investigate the effects of MLC601 on the occurrence of early vascular events within 3 months of stroke onset.
Christopher L.H. Chen, Narayanaswamy Venketasubramanian, Chun Fan Lee, K.S. Lawrence Wong, Marie-Germaine Bousser, Jose C. Navarro, Herminigildo H. Gan, Annabelle Y. Lao, Alejandro C. Baroque, Johnny Lokin, John Harold B. Hiyadan, Ma. Socorro Sarfati, Randolph John Fangonillo, Neil Ambasing, Carlos L. Chua, Ma. Cristina San Jose, Joel M. Advincula, Eli John Berame, Maria Teresa Canete, Narayanaswamy Venketasubramanian, Sherry H.Y. Young, Marlie Jane Mamauag, San San Tay, Shrikant Pande, Umapathi Thirugnanam, Rajinder Singh, Hui Meng Chang, Deidre Anne De Silva, Bernard P.L. Chan, Vijay Sharma, Teoh Hock Luen, Niphon Poungvarin, Sombat Muengtaweepongsa, Somchai Towanabut, Nijasri C. Suwanwela, Songkram Chotickanuchit, Siwaporn Chankrachang, Samart Nitinun, H. Asita de Silva, Udaya Ranawake, Nirmala Wijekoon, K.S. Lawrence Wong, Gaik Bee Eow   +42 more
openaire   +4 more sources