Results 11 to 20 of about 243 (91)

MLC901 in hypoxic-ischemic brain injury patients: A double-blind, randomized placebo-controlled pilot study. [PDF]

Medicine (Baltimore), 2023
Background: Hypoxic-ischemic brain injury (HIBI) is a disabling consequence of cardiopulmonary resuscitation, which has no direct treatment except supportive care. Many studies have used pharmacological agents to reduce or stop this disability. MLC901 is
Pakdaman H, Gharagozli K, Karamiani F, Shamsi Goushki M, Moini S, Sobhanian A, Maghsoudlu F, Esfandani A, Hosseini MH, Amini Harandi A.   +9 more
europepmc   +4 more sources

NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report [PDF]

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window for reperfusion therapy. Studies have proven its efficacy in ischemic stroke; however, data of drug safety and combination with other ...
Anna Misya’il Abdul Rashid, Mohamad Syafeeq Faeez Md Noh, Abdul Hanif Khan Yusof Khan, Wei Chao Loh, Janudin Baharin, Azliza Ibrahim, Liyana Najwa Inche Mat, Wan Aliaa Wan Sulaiman, Fan Kee Hoo, Fazah Akhtar Hanapiah, Hamidon Basri   +10 more
doaj   +3 more sources

Use of MLC901 in cerebral venous sinus thrombosis: Three case reports. [PDF]

World J Clin Cases
BACKGROUND Cerebral venous sinus thrombosis (CVT) is rare cause of cerebrovascular disease. The incidence is 0.5% of all stroke. The majority of affected patients are young adults (mean age: 35-40 years) with mild to moderate disabilities.
Arsovska AA, Venketasubramanian N.
europepmc   +4 more sources

Predictors of Neurological and Functional Recovery in Patients with Moderate to Severe Ischemic Stroke: The EPICA Study [PDF]

Stroke Research and Treatment, 2020
Background. Improving our knowledge about the impact of restorative therapies employed in the rehabilitation of a stroke patient may help guide practitioners in prescribing treatment regimen that may lead to better post-stroke recovery and quality of ...
Manuel Murie-Fernández, Mercedes Molleda Marzo   +1 more
doaj   +3 more sources

The role of MLC901 in reducing VEGF as a vascular permeability marker in rats with spinal cord injury. [PDF]

Ann Med Surg (Lond), 2022
Background Damaged neural tissue caused by SCI could induce vascular endothelial growth factor (VEGF) that can worsen the condition in the late phase by increasing vascular permeability, thus inducing tissue oedema, which can worsen the infarction.
Wahyudi, Islam AA, Hatta M, Adhimarta W, Faris M, Mustamir N, Bukhari A, Prihantono, Kaelan C, Hendarto J, Imran NH, Rosyidi RM.   +11 more
europepmc   +5 more sources

Role of MLC901 in increasing neurogenesis in rats with traumatic brain injury. [PDF]

Ann Med Surg (Lond), 2020
Background Traumatic brain injury is a dangerous life threatening condition. This study examines the role of MLC901 in increasing neurogenesis. The aim of this study was to demonstrate the role of MLC901 in increasing neuron cell (neurogenesis) in rat ...
Rosyidi RM, Priyanto B, Islam AA, Hatta M, Bukhari A, Prihastomo KT, Nasution RA, Rozikin, Prihatina LM.   +8 more
europepmc   +4 more sources

Evaluation of Neuroprotective and Neuroregenerative Potential of NeuroAiD™ II(MLC901) in a Rat Model of Kainic Acid-Induced Spinal Cord Injury. [PDF]

Mol Neurobiol
Excitotoxic damage caused by high extracellular levels of glutamate in the spinal cord results in neuronal loss and severe locomotor impairment. This study investigates the efficacy of NeuroAiD II (MLC901), an herbal formulation, in promoting nerve ...
Anjum A, Yazid MD, Daud MF, Idris J, Ng AMH, Naicker AS, Ismail OHR, Athi Kumar RK, Lokanathan Y.   +8 more
europepmc   +4 more sources

The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia. [PDF]

Sci Rep, 2018
Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke
Widmann C, Gandin C, Petit-Paitel A, Lazdunski M, Heurteaux C.   +4 more
europepmc   +5 more sources

NeuroAid™-II (MLC901) provides neuroprotection and enhances neuronal cell survival against kainic acid-induced excitotoxicity in vitro by activating the PI3K/AKT pathway

Future Journal of Pharmaceutical Sciences
In the twenty-first century, in vitro models of excitotoxic injury, leveraging advanced cellular and molecular technologies, offer a promising alternative to animal studies. These models provide a more precise understanding of injury mechanisms.
Anam Anjum, Muhammad Dain Yazid, Muhammad Fauzi Daud, Jalilah Idris, Angela Min Hwei Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Yogeswaran Lokanathan   +8 more
doaj   +3 more sources

Influence of MLC901 Alone and with Moderate Exercise on Pain Response Concurrent Due to Stress of Male Mice. [PDF]

Galen Med J, 2019
Background: Physical exercise is known to have a positive effect on pain responses induced by stress, while chronic stress causes a negative effect on cognitive abilities.
Nasehi M, Ghazalian F, Shakeri N, Nasehi M, Zarrindast MR.   +4 more
europepmc   +5 more sources