Results 41 to 50 of about 6,744 (203)

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

A structural overview on transformer and transformer-less multi level inverters for renewable energy applications

Energy Reports, 2022
In general, multilevel inverters (MLIs) are regarded as advanced power conversion systems required for medium-voltage and high-power applications. The purpose of this article is to provide an overview of recently investigated MLI topologies classified ...
Dhanamjayulu C., P. Sanjeevikumar, S.M. Muyeen   +2 more
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Lost in aggregation? On the importance of local food price data for food poverty estimates

American Journal of Agricultural Economics, EarlyView.
Abstract This paper explores within‐country variations in food price dynamics and food poverty estimates by employing local market price data and national consumer price index (CPI) data. Our results show that national CPI data may be useful for approximating national trends but they fail to detect and identify spatial variations in local trends, which
Stephan Dietrich, Valerio Giuffrida, Bruno Martorano, Georg Schmerzeck, Marco Tiberti   +4 more
wiley   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

A Comprehensive Review on Space Vector Modulation Techniques for Neutral Point Clamped Multi-Level Inverters

IEEE Access, 2021
The Neutral Point Clamped (NPC) Multi-Level Inverters (MLI) have been ruling the power electronics industries for the past two decades. The Multi-Carrier Pulse Width Modulation (MCPWM) is common PWM techniques which are widely used in NPC-MLI ...
Vinoth Jayakumar, Bharatiraja Chokkalingam, Josiah Lange Munda   +2 more
doaj   +1 more source

African Economic Growth Revisited

Journal of International Development, EarlyView.
ABSTRACT This paper presents an updated analysis of the patterns of economic development in Africa over the last 60 years. The analysis stresses the heterogeneity of development trajectories among sub‐Saharan African (SSA) countries. We examine the joint dynamics of income and population in 35 SSA countries.
Jean‐Paul Chavas, Daniel W. Bromley
wiley   +1 more source

A Single-Phase Single-Source 7-Level Inverter With Triple Voltage Boosting Gain

IEEE Access, 2018
The cascaded H-bridge multilevel inverter (MLI) requires separate isolated dc sources to generate more than three voltage levels and to generate higher output voltage. This paper proposes a new MLI topology that requires only one dc source and is capable
Sze Sing Lee
doaj   +1 more source

Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome

Genome Medicine, 2022
Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and
Jonathan P. Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, Jonathan Braun   +18 more
doaj   +1 more source

Diagnostic Delay of Unilateral Facial Paralysis Caused by Occult Malignancy: A Scoping Review

The Laryngoscope, EarlyView.
This scoping review of 27 studies (66 patients) characterizes unilateral facial paralysis caused by occult malignancy, a rare entity marked by a mean diagnostic delay of 21 months and initially negative imaging in 89% of cases. Progressive paralysis, lack of recovery, trigeminal or additional cranial nerve involvement, and a history of regional skin ...
Kai C. Kokesh, Gabrielle Cahill, Irene Kim, Babak Azizzadeh, G. Nina Lu   +4 more
wiley   +1 more source