Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Analysis of loading of the boom of a dragline excavator
Горное оборудование и электромеханикаThe article discusses a method for determining the forces acting on the elements of the boom of a dragline excavator when the bucket is in position, both in the stretch zone and at other points in the working area.
Brozovsky S.Yu. +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Birth preparedness and complication readiness assessment among antenatal and postnatal mothers at government hospital, in urban Bengaluru [PDF]
Al Ameen Journal of Medical SciencesBackground: Maternal mortality remains a significant public health challenge, particularly in developing countries like India. Birth Preparedness and Complication Readiness (BPACR) is a critical component of antenatal care recommended by the World Health
Sangeetha M.D +4 more
doaj
Aplicação de modelo de revegetação em áreas degradadas, visando à restauração ecológica da microbacia do córrego da Fazenda Itaqui, no município de Santa Gertrudes, SP. Application of revegetation model in degraded areas aiming at the ecological restoration in the catchment of the Itaqui farm stream, Santa Gertrudes municipality, SP, Brazil. [PDF]
Revista do Instituto Florestal, 2005 O trabalho foi executado numa áreadenominada região dos lagos, no município deSanta Gertrudes, SP, situado aproximadamente nocruzamento da latitude 22°27’24”S e a longitude47°31’49”W.
Rosa Maria Galera GONÇALVES +3 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Nasal epithelial zonation and turbinate morphology in infant common marmosets (Callithrix jacchus)
Scientific ReportsThe nasal cavity plays a critical role in respiration and olfaction, functions supported by its turbinate architecture and epithelial distribution. The turbinates—primarily composed of the maxilloturbinate and ethmoturbinate—expand the intranasal surface
Gyeong Min Yoon +11 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source