Results 61 to 70 of about 3,296,150 (267)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Analysis of Stress Relaxation in Jointed Plain Concrete Pavements

The Baltic Journal of Road and Bridge Engineering, 2015
The cracks in concrete pavements are formed at early-age as consequence of internal stresses in the concrete. Therefore, the stress relaxation has an essential influence on the cracking process. To model this process allows to identify, for instance, the
Mauricio Pradena, Lambert Houben
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effects of exogenous salicylic acid on the adaptive capacity of Leymus chinensis seedlings under extreme drought conditions

Frontiers in Plant Science
To investigate the effects of exogenous salicylic acid (SA) on the growth characteristics of Leymus chinensis seedlings under extreme drought stress, this study utilized L.
Chongyang Li, Chongyang Li, Xinying Liu, Xinying Liu, Bin Li, Bin Li, Rong Yang, Rong Yang, Xiangyang Hou, Xiangyang Hou   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Geometrical characteristics of powder particles for hydroabrasive treatment

Известия высших учебных заведений. Поволжский регион:Технические науки, 2021
Background. Modeling the interaction of abrasive grain with the workpiece during hydroabrasive treatment is an important stage in the technological preparation of production.
A.E. Zverovshchikov, G.G. Lebedev, P.A. Gurin   +2 more
doaj   +1 more source

From QM/MM to ML/MM: A new era in multiscale modeling

Chemical Physics Reviews
Hybrid machine-learning/molecular-mechanics (ML/MM) methods extend the classical QM/MM paradigm by replacing the quantum description with neural network interatomic potentials trained to reproduce accurately quantum-mechanical (QM) results. By describing only the chemically active region with ML and the surrounding environment with molecular mechanics (
Juan Santiago Grassano, Ignacio Pickering, Adrian E. Roitberg, Dario A. Estrin, Jonathan A. Semelak   +4 more
openaire   +1 more source

Conditional Diagnosability of Exchanged Hypercube Under the MM* Model

IEEE Access, 2018
Exchanged hypercube $EH(s,t)$ is a typical hypercube variant, which is built up by systematically removing a range of edges from hypercube $Q_{s+t+1}$ . $EH(s,t)$ preserves several advantages of hypercube and has better properties in terms of diameter and cost.
Chen Guo 0005, Ming Leng, Zhifang Xiao, Shuo Peng   +3 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source