Results 91 to 100 of about 11,198,539 (258)
In Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin
Scientifica, 2016 The present study was focused on formulating and evaluating clarithromycin (CLR) containing niosomal formulation for in vitro and in vivo pharmacokinetic behavior.
Gyati Shilakari Asthana +2 more
doaj +1 more source
Sub-mm observations and modelling of Vega type stars
, 2003 We present new sub-mm observations and modelling of Vega excess stars, using realistic dust grain models. For resolved disks, we find that different objects require very different dust grain properties in order to simultaneously fit the image data and ...
Augereau +67 more
core +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Behaviour of composite floor slabs under fire conditions [PDF]
, 2015 This paper is concerned with the ultimate behaviour of composite floor slabs during fire scenarios. Steel/concrete composite structures are increasingly common in the UK and worldwide, particularly for multi-storey construction.
Cashell, KA, Florides, MM
core
MM Algorithms for Minimizing Nonsmoothly Penalized Objective Functions
, 2011 In this paper, we propose a general class of algorithms for optimizing an extensive variety of nonsmoothly penalized objective functions that satisfy certain regularity conditions.
Schifano, Elizabeth D. +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The detectability of mm-wave molecular rotational transitions
, 2016 Elaborating on a formalism that was first expressed some 40 years ago, we consider the brightness of low-lying mm-wave rotational lines of strongly polar molecules at the threshold of detectability.
Liszt, Harvey, Pety, Jerome
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
E3S Web of Conferences, 2018 The objective of this work is to study the relationship of the deformation-strength characteristics of the fastening system with its displacement value. The tendencies of influence are divided into two groups.
Kovalevska Iryna +3 more
doaj +1 more source