Results 91 to 100 of about 11,212,458 (259)

Energy of a knot: variational principles; Mm-energy [PDF]

open access: yes, 2004
Let $E_f$ be the energy of some knot $\tau$ for any $f$ from certain class of functions. The problem is to find knots with extremal values of energy. We discuss the notion of the locally perturbed knot.
Karpenkov, O. N.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Conceptual modelling and the quality of ontologies: A comparison between object-role modelling and the object paradigm [PDF]

open access: yes, 2010
Ontologies are key enablers for sharing precise and machine-understandable semantics among different applications and parties. Yet, for ontologies to meet these expectations, their quality must be of a good standard.
Al-Asswad, MM   +3 more
core  

MM Algorithms for Minimizing Nonsmoothly Penalized Objective Functions

open access: yes, 2011
In this paper, we propose a general class of algorithms for optimizing an extensive variety of nonsmoothly penalized objective functions that satisfy certain regularity conditions.
Schifano, Elizabeth D.   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Numerical Full wave Analysis and Modeling of Plasmonic HEMT Performance Using Hydrodynamic Model

open access: yesInternational Journal of Information and Communication Technology Research, 2019
The two dimensional (2D) plasmon propagation in the channel of a high electron mobility transistor (HEMT) is numerically modeled using the full wave technique.
Farzaneh Daneshmandian   +2 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Behaviour of composite floor slabs under fire conditions [PDF]

open access: yes, 2015
This paper is concerned with the ultimate behaviour of composite floor slabs during fire scenarios. Steel/concrete composite structures are increasingly common in the UK and worldwide, particularly for multi-storey construction.
Cashell, KA, Florides, MM
core  

Sub-mm observations and modelling of Vega type stars

open access: yes, 2003
We present new sub-mm observations and modelling of Vega excess stars, using realistic dust grain models. For resolved disks, we find that different objects require very different dust grain properties in order to simultaneously fit the image data and ...
Augereau   +67 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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