Results 61 to 70 of about 6,374,136 (323)

GOODS-ALMA: 1.1 mm galaxy survey [PDF]

Astronomy & Astrophysics, 2018
Aims. We present a 69 arcmin2 ALMA survey at 1.1 mm, GOODS-ALMA, matching the deepest HST-WFC3 H-band part of the GOODS-South field. Methods. We tapered the 0″24 original image with a homogeneous and circular synthesized beam of 0″60 to reduce the number
Maximilien Franco, D. Elbaz, M. Béthermin, B. Magnelli, C. Schreiber, L. Ciesla, M. Dickinson, N. Nagar, J. Silverman, E. Daddi, D. Alexander, T. Wang, M. Pannella, É. Le Floc'h, A. Pope, M. Giavalisco, A. Maury, F. Bournaud, R. Chary, R. Demarco, H. Ferguson, S. Finkelstein, H. Inami, D. Iono, S. Juneau, G. Lagache, R. Leiton, L. Lin, G. Magdis, H. Messias, K. Motohara, J. Mullaney, K. Okumura, C. Papovich, J. Pforr, W. Rujopakarn, M. Sargent, X. Shu, L. Zhou   +38 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Powered ankle-foot orthoses: the effects of the assistance on healthy and impaired users while walking

Journal of NeuroEngineering and Rehabilitation, 2018
In the last two decades, numerous powered ankle-foot orthoses have been developed. Despite similar designs and control strategies being shared by some of these devices, their performance in terms of achieving a comparable goal varies.
Marta Moltedo, Tomislav Baček, Tom Verstraten, Carlos Rodriguez-Guerrero, Bram Vanderborght, Dirk Lefeber   +5 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing

Italian National Conference on Sensors, 2019
This article presents a broad review on optical, radio-frequency (RF), microwave (MW), millimeter wave (mmW) and terahertz (THz) biosensors. Biomatter-wave interaction modalities are considered over a wide range of frequencies and applications such as ...
Parikha Mehrotra, B. Chatterjee, Shreyas Sen   +2 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Assessing the performance of MM/PBSA and MM/GBSA methods. 8. Predicting binding free energies and poses of protein–RNA complexes

RNA: A publication of the RNA Society, 2018
Molecular docking provides a computationally efficient way to predict the atomic structural details of protein–RNA interactions (PRI), but accurate prediction of the three-dimensional structures and binding affinities for PRI is still notoriously ...
Fu Chen, Huiyong Sun, Junmei Wang, Feng Zhu, Hui Liu, Zhe Wang, Tailong Lei, Youyong Li, Tingjun Hou   +8 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source