Results 71 to 80 of about 187,190 (297)

2D cross-hole MMR - survey design and sensitivity analysis for cross-hole applications of the magnetometric resistivity method [PDF]

, 2009
The magnetometric resistivity (MMR) method measures low-level (typically < 1nT) magnetic fields associated with a low-frequency (1 - 20 Hz) electric current impressed into the ground to determine the subsurface resistivity structure.
Fielitz, Daniel
core  

On the migration of two planets in a disc and the formation of mean motion resonances

, 2015
We study the dynamics of a system of two super-Earths embedded in a protoplanetary disc. We build a simple model of an irradiated viscous disc and use analytical prescriptions for the planet-disc interactions which lead to migration.
Migaszewski, Cezary
core   +1 more source

Insights on the dynamical history of the Fomalhaut system - Investigating the Fom c hypothesis [PDF]

, 2014
The eccentric shape of the debris disk observed around Fomalhaut was first attributed to Fom b, a companion detected near the belt inner-edge, but new constraints on its orbit revealed that it is belt-crossing, highly eccentric $(e \sim 0.6-0.9)$, and ...
Augereau, Jean-Charles, Beust, Hervé, Faramaz, Virginie, Graham, James R., Kalas, Paul   +4 more
core   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Dynamics of Jupiter Trojans during the 2:1 mean motion resonance crossing of Jupiter and Saturn [PDF]

, 2007
We study the dynamics of Jupiter Trojans in the early phase of the Solar system while the outer planets migrated due to their interaction with the planetesimal disk.Comment: 10 pages, 17 ...
Duncan, Erdi, Everhart, F. Marzari, Fernandez, Fleming, H. Scholl, Horner, Karlsson, Kley, Kortenkamp, Laskar, Laskar, Laskar, Lee, Malhotra, Marzari, Marzari, Marzari, Marzari, Marzari, Michtchenko, Morbidelli, Murray, Namouni, Nesvorny, Robutel, Tsiganis   +27 more
core   +4 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A comparison of heart failure patients with reduced ejection fraction in the Moravian Midlands Registry with the LCZ696 patients in the Paradigm-HF trial

Biomedical Papers
Background and Aims. There are limited data on real clinical practice in heart failure patients in the Czech Republic. We analysed the clinical parameters from the Moravian Midlands Registry (MMR) and compared them to LCZ696 patients in the Paradigm-HF ...
Ludek Pavlu, Marek Vicha, Jakub Flasik, Jana Petrkova, Milos Taborsky, Tereza Kacirkova, Ondrej Holy   +6 more
doaj   +1 more source