Results 81 to 90 of about 187,190 (297)

AMD-stability in presence of first order Mean Motion Resonances

, 2017
The AMD-stability criterion allows to discriminate between a-priori stable planetary systems and systems for which the stability is not granted and needs further investigations.
Boué, Gwenaël, Laskar, Jacques, Petit, Antoine C.   +2 more
core   +3 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Enhancing Biogenic Formic Acid Production in the Modified OxFA Process by Acetonitrile Addition

Advanced Science, EarlyView.
In this study, the beneficial effect of using acetonitrile as a co‐solvent in the modified OxFA process is shown, outperforming methanol, demonstrating improved reaction kinetics combined with high selectivity for the HPA‐2 (H5PV2Mo10O40) catalyzed oxidation of xylose to FA.
Jan‐Dominik H. Krueger, Pegah Saedi, Maximilian J. Poller, Alberto Collauto, Jason P. Hallett, David Robinson, Maxie M. Roessler, Jakob Albert   +7 more
wiley   +1 more source

An Overview of the 13:8 Mean Motion Resonance between Venus and Earth

, 2009
It is known since the seminal study of Laskar (1989) that the inner planetary system is chaotic with respect to its orbits and even escapes are not impossible, although in time scales of billions of years.
A. Hanslmeier, C. Froeschlé, C. Froeschlé, Ch. Lhotka, E. Pilat-Lohinger, E. Pilat-Lohinger, F. Varadi, G.J. Sussman, H. Lichtenegger, J. Candy, J. Dufey, J. Laskar, J. Laskar, J. Laskar, J. Laskar, J. Laskar, J.E. Chambers, J.H. Applegate, J.L. Wisdom, K. Batygin, M. Delva, M. Henon, N. Murray, P. Reegen, R. Dvorak, R. Dvorak, R. Schwarz, S. Michtchenko, T. Kallinger, V. Eybl, Á. Bazsó   +30 more
core   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Response to third rubella vaccine dose

Human Vaccines & Immunotherapeutics, 2018
Limited data exist on the immunogenicity of a third dose of the measles, mumps, and rubella vaccine (MMR). In this study, our aim was to evaluate the long-term rubella immunogenicity afforded by two childhood MMR doses of the Norwegian vaccination ...
Lotta Siira, Hanne Nøkleby, Regine Barlinn, Øystein R. Riise, Ingeborg S. Aaberge, Susanne G. Dudman   +5 more
doaj   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial

Human Vaccines & Immunotherapeutics, 2019
Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected.
Tetsuo Nakayama, Masahiro Eda, Motonori Hirano, Wakako Goto   +3 more
doaj   +1 more source