Results 1 to 10 of about 33,968 (250)

Magnetic-Measuring Square in the Measurement of the Circular Curve of Rail Transport Tracks

Sensors, 2020
In rail transport, measuring the actual condition of a circular curve of a railway track is a key element of track position monitoring not only during operation but also during final works.
Arkadiusz Kampczyk
doaj   +1 more source

From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Since the outbreak of the COVID-19 pandemic in December 2019, the SARS-CoV-2 genome has undergone several mutations. The emergence of such variants has resulted in multiple pandemic waves, contributing to sustaining to date the number of infections ...
Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +3 more
doaj   +1 more source

Re-Exploring the Ability of Common Docking Programs to Correctly Reproduce the Binding Modes of Non-Covalent Inhibitors of SARS-CoV-2 Protease M^pro

Pharmaceuticals, 2022
In the latest few decades, molecular docking has imposed itself as one of the most used approaches for computational drug discovery. Several docking benchmarks have been published, comparing the performance of different algorithms in respect to a ...
Davide Bassani, Matteo Pavan, Giovanni Bolcato, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Bat coronaviruses related to SARS-CoV-2: what about their 3CL proteases (MPro)?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Despite a huge effort by the scientific community to determine the animal reservoir of SARS-CoV-2, which led to the identification of several SARS-CoV-2-related viruses both in bats and in pangolins, the origin of SARS-CoV-2 is still not clear. Recently,
Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +3 more
doaj   +1 more source

Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The chemical structure of PF-07321332, the first orally available Covid-19 clinical candidate, has recently been revealed by Pfizer. No information has been provided about the interaction pattern between PF-07321332 and its biomolecular counterpart, the ...
Matteo Pavan, Giovanni Bolcato, Davide Bassani, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Ribose and Non-Ribose A2A Adenosine Receptor Agonists: Do They Share the Same Receptor Recognition Mechanism?

Biomedicines, 2022
Adenosine receptors have been a promising class of targets for the development of new therapies for several diseases. In recent years, a renewed interest in this field has risen, thanks to the implementation of a novel class of agonists that lack the ...
Giovanni Bolcato, Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Estimation and Adjustment of Polarization Errors in Conical Scan Method

Известия высших учебных заведений России: Радиоэлектроника, 2018
The article proposes a solution of a problem of polarization error compensation for radar object direction finding by means of conical scan method.
A. A. Bludov, G. A. Gorbatovskij, V. S. Pavlov, A. F. Suvorov   +3 more
doaj   +1 more source

Comparative antibacterial properties in vitro of seven olivanic acid derivatives: MM 4550, MM 13902, MM 17880, MM 22380, MM 22381, MM 22382 and MM 22383.

The Journal of Antibiotics, 1980
Streptomyces olivaceus ATCC 31365 produces a family of novel beta-lactam antibiotics collectively referred to as the olivanic acids. Seven such compounds, MM 4550, MM 13902, MM 17880, MM 22380, MM 22381, MM 22382 and MM 22383 have been identified which have the same carbapenem nucleus but with different side chains attached to the nucleus.
M J, Basker, R J, Boon, P A, Hunter
openaire   +3 more sources

Sodium or Not Sodium: Should Its Presence Affect the Accuracy of Pose Prediction in Docking GPCR Antagonists?

Pharmaceuticals, 2022
The function of the allosteric sodium ion in stabilizing the inactive form of GPCRs has been extensively described in the past decades. Its presence has been reported to be essential for the binding of antagonist molecules in the orthosteric site of ...
Davide Bassani, Matteo Pavan, Mattia Sturlese, Stefano Moro   +3 more
doaj   +1 more source

Multipoint MMS observations of fine‐scale SAPS structure in the inner magnetosphere

Geophysical Research Letters, 2016
We present detailed observations of dynamic, fine‐scale inner magnetosphere‐ionosphere coupling at ∼3.9 RE in the Region 2 Birkeland field‐aligned current (FAC). We find that observed electrodynamic spatial/temporal scales are primarily characteristic of
P. J. Erickson, H. Matsui, J. C. Foster, R. B. Torbert, R. E. Ergun, Yu. V. Khotyaintsev, P.‐A. Lindqvist, M. R. Argall, C. J. Farrugia, K. W. Paulson, R. J. Strangeway, W. Magnes   +11 more
doaj   +1 more source