Results 11 to 20 of about 55,884 (291)

Magnetic-Measuring Square in the Measurement of the Circular Curve of Rail Transport Tracks

Sensors, 2020
In rail transport, measuring the actual condition of a circular curve of a railway track is a key element of track position monitoring not only during operation but also during final works.
Arkadiusz Kampczyk
doaj   +1 more source

From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Since the outbreak of the COVID-19 pandemic in December 2019, the SARS-CoV-2 genome has undergone several mutations. The emergence of such variants has resulted in multiple pandemic waves, contributing to sustaining to date the number of infections ...
Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +3 more
doaj   +1 more source

Re-Exploring the Ability of Common Docking Programs to Correctly Reproduce the Binding Modes of Non-Covalent Inhibitors of SARS-CoV-2 Protease M^pro

Pharmaceuticals, 2022
In the latest few decades, molecular docking has imposed itself as one of the most used approaches for computational drug discovery. Several docking benchmarks have been published, comparing the performance of different algorithms in respect to a ...
Davide Bassani, Matteo Pavan, Giovanni Bolcato, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

unh-mms-rogers/mms-curvature: MMS-Curvature Functioning Beta

, 2022
This contains a functioning implementation of the method of reciprocal vectors, as found in Chateur et alia (1998), for calculating the gradient of a vector field from 4 vertices in a tetrahedron configuration.
Anthony Rogers, Tim Rogers
core   +1 more source

Bat coronaviruses related to SARS-CoV-2: what about their 3CL proteases (MPro)?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Despite a huge effort by the scientific community to determine the animal reservoir of SARS-CoV-2, which led to the identification of several SARS-CoV-2-related viruses both in bats and in pangolins, the origin of SARS-CoV-2 is still not clear. Recently,
Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +3 more
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Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The chemical structure of PF-07321332, the first orally available Covid-19 clinical candidate, has recently been revealed by Pfizer. No information has been provided about the interaction pattern between PF-07321332 and its biomolecular counterpart, the ...
Matteo Pavan, Giovanni Bolcato, Davide Bassani, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Ribose and Non-Ribose A2A Adenosine Receptor Agonists: Do They Share the Same Receptor Recognition Mechanism?

Biomedicines, 2022
Adenosine receptors have been a promising class of targets for the development of new therapies for several diseases. In recent years, a renewed interest in this field has risen, thanks to the implementation of a novel class of agonists that lack the ...
Giovanni Bolcato, Matteo Pavan, Davide Bassani, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Estimation and Adjustment of Polarization Errors in Conical Scan Method

Известия высших учебных заведений России: Радиоэлектроника, 2018
The article proposes a solution of a problem of polarization error compensation for radar object direction finding by means of conical scan method.
A. A. Bludov, G. A. Gorbatovskij, V. S. Pavlov, A. F. Suvorov   +3 more
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Mutagenic potency of MMS-induced 1meA/3meC lesions in E. coli. [PDF]

, 2009
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation and their repair by cellular defense systems. Among the lesions in methylated DNA is 1meA/3meC, which is recently recognized as being mutagenic.
Janion, Celina, Jadwiga Nieminuszczy, Sikora, Anna, Joanna Krwawicz, Mielecki, Damian, Wrzesiński, Michał, MichaÅ WrzesinÌski, Celina Janion, Krwawicz, Joanna, Grzesiuk, Elzbieta, Anna Sikora, ElzÌbieta Grzesiuk, Nieminuszczy, Jadwiga, Damian Mielecki, Aleksandra Chojnacka, Chojnacka, Aleksandra   +15 more
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Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair. [PDF]

, 2010
Methylmethane sulphonate (MMS), an S(N)2-type alkylating agent, generates DNA methylated bases exhibiting cytotoxic and mutagenic properties. Such damaged bases can be removed by a system of base excision repair (BER) and by oxidative DNA demethylation ...
Sikora, Anna, Grzesiuk, Elzbieta, A. Sikora, J. Nieminuszczy, Mielecki, Damian, D. Mielecki, A. Chojnacka, Nieminuszczy, Jadwiga, Wrzesiński, Michał, M. Wrzesinski, E. Grzesiuk, Chojnacka, Aleksandra   +11 more
core   +1 more source