Results 111 to 120 of about 152,985 (282)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Dust Polarization of Prestellar and Protostellar Sources in OMC-3

The Astrophysical Journal
We present the Atacama Large Millimeter/submillimeter Array observations of linearly polarized 1.1 mm continuum emission at ∼0.″14 (55 au) resolution and CO ( J = 2−1) emission at ∼1.″5 (590 au) resolution toward one prestellar (MMS 4), four Class 0 (MMS
Yuhua Liu, Satoko Takahashi, Masahiro Machida, Kohji Tomisaka, Josep Miquel Girart, Paul T. P. Ho, Kouichiro Nakanishi, Asako Sato   +7 more
doaj   +1 more source

An Efficient Multiway Mergesort for GPU Architectures

, 2017
Sorting is a primitive operation that is a building block for countless algorithms. As such, it is important to design sorting algorithms that approach peak performance on a range of hardware architectures.
Casanova, Henri, Iacono, John, Karsin, Ben, Sitchinava, Nodari, Weichert, Volker   +4 more
core  

EFFICIENT RISK DETERMINATION OF RISK OF ROAD BLOCKING BY MEANS OF MMS AND DATA OF BUILDINGS AND THEIR SURROUNDING [PDF]

, 2016
Kazuhito Nose, Shuhei Hatake
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of magnesium slag and fly ash on strength and hydration mechanism of binary and ternary blended cement mortar

Case Studies in Construction Materials
Utilizing industrial waste residue in construction is regarded as a crucial technology for advancing renewable resource products and optimizing waste resource use.
Meng Gao, Hongjun Jing, Jun Dai, Wanjun Ye   +3 more
doaj   +1 more source

Pertambahan Berat Badan (PBB) dan Peningkatan Nilai Jual (PNJ) Sapi Bali dengan Pemberian Molasses Multinutrien Soft (MMS) Level 15% Dan 20%

, 2023
Reynildis Koronka Pahtra Sulo, Syarifuddin Syarifuddin, Ahmad Muchlis   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Simulation of intercalation and phase transitions in nano-porous, polycrystalline agglomerates

npj Computational Materials
Optimal microstructure design of battery materials is critical to enhance the performance of batteries for tailored applications such as high power cells.
Simon Daubner, Marcel Weichel, Martin Reder, Daniel Schneider, Qi Huang, Alexander E. Cohen, Martin Z. Bazant, Britta Nestler   +7 more
doaj   +1 more source