Results 51 to 60 of about 55,884 (291)
Immune-mediated genesis of multiple sclerosis
Journal of Translational Autoimmunity, 2020 Multiple sclerosis (MS) is widely acknowledged to be an autoimmune disease affecting the neuronal myelin structure of the CNS. Autoantigens recognized as the target of this autoimmune process are: myelin basal protein, anti-proteolipid protein ...
Salvatore Cavallo, MD, Specialist in Medical Genetics
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Molecules, 2019 One of the most intriguing findings highlighted from G protein-coupled receptor (GPCR) crystallography is the presence, in many members of class A, of a partially hydrated sodium ion in the middle of the seven transmembrane helices (7TM) bundle.
Maicol Bissaro +4 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Статистика и экономика, 2016 The article describes enterprise mathmodels, its interactions with environment in commodity market and quantitativeconditions for its success and the crisis in such kind of interaction. Showed: the number of commodity market successfulparticipants should
Boris V. Mednikov +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Fragment-based lead discovery (FBLD) is one of the most efficient methods to develop new drugs. We present here a new computational protocol called High-Throughput Supervised Molecular Dynamics (HT-SuMD), which makes it possible to automatically screen ...
Francesca Ferrari +7 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
uv (visibility) continuum and spectral line data for L1451-MMS (L1451MMS, L1451 MMS, L1451 ...
Stephens, Ian
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PLoS ONE, 2020 The liquid foodstuffs such as edible oil products remain a problem of excessive aflatoxin B1 (AFB1) content. This paper focused on the preparation of magnetic mesoporous silica (MMS) from rice husk ash for the removal of AFB1 in oil system.
Yanan Li +8 more
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Вестник Северо-Кавказского федерального университета, 2022 Around the world, much attention is paid to the new communication technology IEC 61850. A special place is occupied by the program of Digitization of the electric grid complex of the Russian Federation, according to which 40 digital substations will ...
Daria Tuchina +3 more
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