Results 71 to 80 of about 2,693,578 (146)
Lactobacillus reuteri‐mediated dietary xylooligosaccharides enhance jejunal cell survival via suppression of oxygen‐dependent apoptotic processes in a pig model
iMeta, Volume 4, Issue 5, October 2025.Interactions between functional oligosaccharides and small intestinal cells are increasingly recognized as critical for maintaining intestinal health. Using xylooligosaccharides (XOS) as a model, we demonstrate that XOS promote growth in piglets primarily by enhancing nutrient transport and increasing villus height in the jejunum.Fuli Deng, Chang Yin, Chengzeng Luo, Ye Xu, Yuxia Chen, Ruqing Zhong, Shanlong Tang, Hongfu Zhang, Liang Chen +8 morewiley +1 more sourceDecrease of disease‐related metabolites upon fasting in a hemizygous knock‐in mouse model ( Mut ‐ko/ki) of methylmalonic aciduria [PDF]
, 2020 Methylmalonyl‐CoA mutase (MMUT) is part of the propionyl‐CoA catabolic pathway, responsible for the breakdown of branched‐chain amino acids, odd‐chain fatty acids and the side‐chain of cholesterol.Mathis, Déborah, Froese, D Sean; https://orcid.org/, Fingerhut, Ralph, Baumgartner, Matthias R; https://orcid.org/, Perkins, Nathan, Lucienne, Marie, Déborah Mathis, Matthias R. Baumgartner, Baumgartner, Matthias R., Marie Lucienne, Nathan Perkins, D. Sean Froese, Froese, D. Sean, Ralph Fingerhut +13 morecore +1 more sourceAdditional file 7 of Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Additional file 7: Figure S4. Total merit genomic index (ISOLg) of the 2021 MTR genomic cohort lambs (n = 714). (a) Distribution of ISOLg, determined by a combination of four selected traits: MY, FC, PC and LSCS. Comparison of ISOLg according to DHH status, (b) MTRDHH1, (c) MTRDHH2, (d) MTRDHH3, (e) MTRDHH4, (f) MTRDHH5.Ben Braiek, Maxime, Moreno-Romieux, Carole, André, Céline, Astruc, Jean-Michel, Bardou, Philippe, Bordes, Arnaud, Debat, Frédéric, Fidelle, Francis, Granado-Tajada, Itsasne, Hozé, Chris, Plisson-Petit, Florence, Rivemale, François, Sarry, Julien, Tadi, Némuel, Woloszyn, Florent, Fabre, Stéphane +15 moreopenaire +1 more sourceAdditional file 9 of Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Additional file 9: Figure S5. MTRDHH1 recombinant haplotypes from 15 animals with discrepancy between MTRDHH1 status and MMUT SNV genotype. MTRDHH1/ + and + / + refer to heterozygous and non-carriers of MTRDHH1, respectively. The grey column represents the localization of the MMUT SNV (g.23,776,347G > A) within the MTRDHH1 haplotype. For each animal,Ben Braiek, Maxime, Moreno-Romieux, Carole, André, Céline, Astruc, Jean-Michel, Bardou, Philippe, Bordes, Arnaud, Debat, Frédéric, Fidelle, Francis, Granado-Tajada, Itsasne, Hozé, Chris, Plisson-Petit, Florence, Rivemale, François, Sarry, Julien, Tadi, Némuel, Woloszyn, Florent, Fabre, Stéphane +15 moreopenaire +1 more sourceHepatic gluconeogenesis and regulatory mechanisms in lactating ruminants: A literature review
Animal Research and One Health, Volume 3, Issue 3, Page 230-239, August 2025.phosphoenolpyruvate carboxy kinase, FBP1, and glucose‐6‐phosphatase are key rate‐limiting enzymes that determine the efficiency of gluconeogenesis. The main substrate for gluconeogenesis in the liver of ruminants is propionate, which provides more than 60% of the carbon source for gluconeogenesis.Guoyan Wang, Yuanyuan Zhu, Dingping Feng, Junhu Yao, Yangchun Cao, Lu Deng +5 morewiley +1 more sourceAdditional file 10 of Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Additional file 10: Table S6. MMUT SNV genotype distribution from a DNA diversity panel of French and Spanish ovine breeds.Ben Braiek, Maxime, Moreno-Romieux, Carole, André, Céline, Astruc, Jean-Michel, Bardou, Philippe, Bordes, Arnaud, Debat, Frédéric, Fidelle, Francis, Granado-Tajada, Itsasne, Hozé, Chris, Plisson-Petit, Florence, Rivemale, François, Sarry, Julien, Tadi, Némuel, Woloszyn, Florent, Fabre, Stéphane +15 moreopenaire +1 more sourceAdditional file 2 of Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Additional file 2: Table S1. EMBL-EBI accession numbers of the 100 whole-genome sequences used in the analysis [15, 26, 49–51].Ben Braiek, Maxime, Moreno-Romieux, Carole, André, Céline, Astruc, Jean-Michel, Bardou, Philippe, Bordes, Arnaud, Debat, Frédéric, Fidelle, Francis, Granado-Tajada, Itsasne, Hozé, Chris, Plisson-Petit, Florence, Rivemale, François, Sarry, Julien, Tadi, Némuel, Woloszyn, Florent, Fabre, Stéphane +15 moreopenaire +1 more sourceAdditional file 3 of Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Additional file 3: Table S2. List of PCR primer sequences.Ben Braiek, Maxime, Moreno-Romieux, Carole, André, Céline, Astruc, Jean-Michel, Bardou, Philippe, Bordes, Arnaud, Debat, Frédéric, Fidelle, Francis, Granado-Tajada, Itsasne, Hozé, Chris, Plisson-Petit, Florence, Rivemale, François, Sarry, Julien, Tadi, Némuel, Woloszyn, Florent, Fabre, Stéphane +15 moreopenaire +1 more sourceAdditional file 8 of Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Additional file 8: Table S5. Candidate variants located in the MTRDHH1 region.Ben Braiek, Maxime, Moreno-Romieux, Carole, André, Céline, Astruc, Jean-Michel, Bardou, Philippe, Bordes, Arnaud, Debat, Frédéric, Fidelle, Francis, Granado-Tajada, Itsasne, Hozé, Chris, Plisson-Petit, Florence, Rivemale, François, Sarry, Julien, Tadi, Némuel, Woloszyn, Florent, Fabre, Stéphane +15 moreopenaire +1 more sourceAssociation of the CCR5 gene with juvenile idiopathic arthritis [PDF]
, 2010 The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton +22 morecore +1 more source
