Results 81 to 90 of about 2,693,578 (146)

Methylmalonic acidemia caused by Homozygous Missense variant c.1837C>T in Exon 11 of the MMUT gene which is Variant of Uncertain Significance: A Case Report

Fortune Journal of Health Sciences, 2023
G Durga Phani Kumar, Mashingbonio Dirinamai, Bhutwala Senky Manishkumar, Susheel kumar Saini, Ajay kumar Saini, Seema kumari   +5 more
openaire   +1 more source

Naturally occurring cobalamin (B₁₂) analogs can function as cofactors for human methylmalonyl-CoA mutase

Cobalamin, commonly known as vitamin B12, is an essential micronutrient for humans because of its role as an enzyme cofactor. Cobalamin is one of over a dozen structurally related compounds - cobamides - that are found in certain foods and are produced ...
Sokolovskaya OM, Plessl T, Bailey H, Froese DS, Mackinnon S, Taga ME, Yue WW, Baumgartner MR   +7 more
core   +4 more sources

Effects of dietary rumen-protected choline supplementation on genome-wide DNA methylation in mammary tissue from postpartum dairy cows

JDS Communications
Choline is a methyl donor that may influence DNA methylation, gene expression, and cellular processes. Past studies have found an increase in milk yield when periparturient dairy cows were supplemented with dietary rumen-protected choline (RPC); however,
A. Celemin Sarmiento, B.J. Bradford, L.K. Mamedova, G. Zhou, K.A. Estes, T.H. Swartz   +5 more
doaj   +1 more source

Promoter hypomethylation of CDH7: a novel epigenetic marker associated with cerebral small vessel disease

Frontiers in Genetics
IntroductionCerebral small vessel disease (SVD), manifesting as white matter hyperintensities (WMH), lacunar infarctions, and cerebral microbleeds on magnetic resonance imaging (MRI), has been linked to developmental epigenetic alterations.
Jeeyeon Kim, Jeeyeon Kim, Jihye Park, Keunsoo Kang, Young Ho Lee, Byoung-Soo Shin, Dae-Hyun Kim, Dong-Ick Shin, Seong Hwan Ahn, Jae Guk Kim, Hyun Goo Kang, Hyeseon Jeong, Kyu Sun Yum, Hee-Yun Chae, Do-Hyung Kim, Jei Kim, Jei Kim   +16 more
doaj   +1 more source

Pharmacogenomic Pathways Underlying Variable Vedolizumab Response in Crohn’s Disease Patients: A Rare-Variant Analysis

Biomedicines
Background/Objectives: Vedolizumab (VDZ), a monoclonal antibody targeting α4β7 integrin, is used in Crohn’s disease (CD) management, yet patients’ responses vary, underscoring the need for pharmacogenomic (PGx) markers.
Biljana Stankovic, Mihajlo Stasuk, Vladimir Gasic, Bojan Ristivojevic, Ivana Grubisa, Branka Zukic, Aleksandar Toplicanin, Olgica Latinovic Bosnjak, Brigita Smolovic, Srdjan Markovic, Aleksandra Sokic Milutinovic, Sonja Pavlovic   +11 more
doaj   +1 more source

Solubilized P and biomass produced by Aspergillus niger FS1 mutants compared to the wild type.

, 2014
The experiments were carried out in liquid NBRIP medium supplemented with F− at 50 mg L−1 (NBRIP-F) or NBRIP with 3 g L−1 of Araxá RP as the only P source.
Josiane Leal Duarte (643661), Gilberto de Oliveira Mendes (643659), Ubiana de Cássia Silva (643658), Nina Morena R. M. Silva (643660), Marcos Rogério Tótola (643662), Ivo Ribeiro Silva (425268), Maurício Dutra Costa (429578)   +6 more
core   +1 more source

Vitamin B12 Alleviates Hepatic Ischemia–Reperfusion Injury with Restoration of Propanoate Metabolism and Mitochondrial Function

Journal of Inflammation Research
Simeng Lei,1,2,* Zhenyu Zheng,3,* Hao Wang,2,4,* Hanwen Yang,1,2 Yuepeng Wang,5 Bo Zhang,1,2 Yangkai Fu,1,2 Zhen Li,6 Zhili Ji1,21Division of Hepatobiliary and Pancreaticosplenic Surgery, Department of General Surgery, Beijing ...
Lei S, Zheng Z, Wang H, Yang H, Wang Y, Zhang B, Fu Y, Li Z, Ji Z   +8 more
doaj  

MIS-C, inherited metabolic diseases and methylmalonic acidemia: a case report and review of the literature

Italian Journal of Pediatrics
Background Methylmalonic acidemia (MMA) secondary to mutase deficiency, mut0, is an inborn error of metabolism causing complete enzyme defect, allowing a high risk of irreversible complications, secondary to metabolic decompensation, induced by ...
Maria Cristina Maggio, Cinzia Castana, Marina Caserta, Antonella Di Fiore, Vittoria Siciliano, Giovanni Corsello   +5 more
doaj   +1 more source

Investigating the genetic and epigenetic architecture of Mesoamerican nephropathy [PDF]

Mesoamerican nephropathy (MeN) is a leading cause of death amongst working-age men in many Central American countries. Renal biopsy data suggests the disease is caused by a chronic tubulointerstitial nephritis, and numerous environmental agents such as ...
Oomatia, Amin
core   +1 more source

Methylmalonate Overload Despite Glycemic Control Drives Diabetic Heart Damage

BACKGROUND: Despite optimal glycemic control, the heart failure burden remains substantial in diabetic patients.
Ye Wang, Xiaoxuan Liu, Yuanyuan Huang, Miao Yan, Rongze Lu, Zhaoying Li, Yanjiao Shen, Yan Cui, Junchen Guo, Xing Luo, Bo Yu, Shaohong Fang, Pengyan Wu, Yiying Zhang, Dongdong Sun, Zhuozhong Wang, Wen Ge, Zhanchao Chen, Shanjie Wang, Guanpeng Ma, Shuang Yang, Hengxuan Cai, Fan Tang, Zeng Wang, Yige Liu   +24 more
core   +1 more source