Association of Proton Pump Inhibitor and Potassium-Competitive Acid Blocker Use With Discontinuation and Intolerance of Oral 5-Aminosalicylic Acid in Patients With Ulcerative Colitis. [PDF]
ABSTRACT Aims Proton pump inhibitors (PPIs) and potassium‐competitive acid blockers (PCABs) are widely used for acid‐related disorders. Recent studies have raised concerns that acid suppression may alter gut microbiota and drug pharmacokinetics, potentially influencing therapeutic outcomes in patients with inflammatory bowel disease.
Otagiri S +4 more
europepmc +2 more sources
Repeated (Weekly) Intra-Articular Injections of Sulfated Galactans Attenuate Cartilage Degeneration in a Rat Model of Osteoarthritis. [PDF]
Knee osteoarthritis (OA) is characterized by progressive cartilage degeneration and remains a major cause of joint dysfunction with limited disease‐modifying therapies. This study evaluated the therapeutic potential of sulfated galactans (SG) extracted from Gracilaria fisheri in a rat OA model induced by anterior cruciate ligament transection and ...
Srianake N +8 more
europepmc +2 more sources
Science objectives of the MMX rover
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing ...
Hideaki Miyamoto +2 more
exaly +4 more sources
The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study [PDF]
Background: Recently, a new biomarker index that reflects inflammation and protein energy malnutrition has emerged as a predictor of mortality in cardiovascular diseases. The metabolic vulnerability index (MVX) derives from blood-based inflammation (IVX)
Carolina Castro Porto Silva Janovsky +14 more
doaj +2 more sources
Frailty Exacerbates Disability in Progressive Multiple Sclerosis. [PDF]
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Wicks TR +10 more
europepmc +2 more sources
Correction to 'Associations of Multimarkers of Metabolic Malnutrition and Inflammation With All-Cause Mortality and Their Interplay With Thyroid Function'. [PDF]
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
europepmc +2 more sources
Medial Meniscectomy at the Time of ACL Reconstruction Is Associated With Postoperative Anterior Tibial Translation: A Retrospective Analysis [PDF]
Background: Medial meniscal pathology and management have not been associated with postoperative anterior tibial translation (ATT) after anterior cruciate ligament reconstruction (ACLR).
Andrew Fithian MD +7 more
doaj +2 more sources
The WheelCams on the IDEFIX rover [PDF]
IDEFIX, the Martian Moons eXploration (MMX) mission Phobos rover, will be the first of its kind to attempt wheeled-locomotion on a low-gravity surface.
Naomi Murdoch +27 more
doaj +2 more sources
Evaluation of the efficacy of MMX mesalazine therapy for moderate ulcerative colitis
Introduction. Treatment of patients with ulcerative colitis (UC) requires continuous anti-relapse therapy. Mesalazines are the firstline disease-modifying drugs for the treatment of mild to moderate UC to manage exacerbations and to induce and maintain ...
O. V. Knyazev +2 more
doaj +1 more source
Optimization of approaches to the treatment of mild to moderate ulcerative colitis
Ulcerative colitis is an autoimmune disease of the colon, manifested by the development of non-specific inflammation of its mucous membrane with a mandatory lesion of the rectum.
S. S. Belous, O. V. Knyazev
doaj +1 more source

