Results 21 to 30 of about 3,489 (154)

A parthenogenetic maternal and double paternal contribution to an ovotesticular disorder of sex development [PDF]

, 2014
BACKGROUND: An ovotesticular disorder of sex development (OT-DSD) was rarely found in human. The mechanism causing such condition is poorly understood. We hereby reported a 11-year-old child with OT-DSD and a karyotype 46,XX/46,XY, a single maternal and ...
Cui Zhang, Hong-Liu Gao, Na Li, Qiu-Yue Wu, Tian-Fu Li, Wei-Ping Wang, Wei-Wei Li, Xiao-Jun Li, Xin-Yi Xia, Ying-Xia Cui   +9 more
core   +1 more source

A cross-sectional pilot study to estimate the frequency of minor blood group alleles and phenotypes in RhD-negative North Indian blood donors by DNA microarray analysis

Asian Journal of Transfusion Science
INTRODUCTION: There are scarce data on Indian blood donors with respect to blood group phenotypes using molecular diagnostic modalities. Hence, we planned to estimate frequencies of blood group alleles/phenotypes using DNA microarray analysis in the ...
Gita Negi, Sheetal Malhotra, Bela Goyal, Praveen Kumar Singh, Anissa Atif Mirza   +4 more
doaj   +1 more source

Distribution of Clinically Relevant Blood Group Antigens among Nigerians and the Management of Rhesus D Negative Pregnancies: Implications for Haemolytic Disease of the Foetus and Newborn and Haemolytic Transfusion Reactions [PDF]

, 2019
The ABO and Rhesus blood group systems are the most clinically relevant blood group systems from haemolytic disease of the foetus and newborn (HDFN) and haemolytic transfusion reaction (HTR) perspectives.
Adias, Teddy Charles, Erhabor, Osaro, Erhabor, Tosan, Polycarp, Iwueke Ikechukwu   +3 more
core   +2 more sources

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Neuroprotective Potential of Ethoxzolamide Targeting Oxidative Stress and Inflammation in Experimental Models of Intracerebral Hemorrhage

Frontiers in Bioscience-Landmark
Background: As antioxidant and anti-inflammatory agents, carbonic anhydrase inhibitors can exert potentially useful therapeutic effects following central nervous system trauma, including intracerebral hemorrhage (ICH).
Yongxia Li, Gang Shen, Jiarui Du, Wei Dai, Zuopeng Su   +4 more
doaj   +1 more source

Melatonin mitigates type 1 diabetes‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects [PDF]

, 2023
IntroductionCerebral ischemia and diabetes mellitus (DM) are common diseases that often coexist and interact with each other. DM doubles the risk of ischemic stroke, and cerebral ischemia causes stress-induced hyperglycemia.
Cheung, Raymond Tak Fai, Xu, Qian
core   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Alloimmunization in blood transfusion´s recipients in UH Motol [PDF]

, 2017
V této práci se budeme zabývat odpovědí organismu na cizí antigeny, které v našem případě organismus přijímá při podání krevní transfuze pacientovi. Mimo jiné k tomuto procesu může docházet také v těhotenství při přítomnosti rozdílného antigenu matky a ...
Drunecká Veronika
core  

AT2 activation does not influence brain damage in the early phase after experimental traumatic brain injury in male mice [PDF]

, 2022
Antagonism of the angiotensin II type 1 receptor (AT1) improves neurological function and reduces brain damage after experimental traumatic brain injury (TBI), which may be partly a result of enhanced indirect angiotensin II type 2 receptor (AT2 ...
Bardon, Andreas Garcia, Coronel-Castello, Shila P., Griemert, Eva-Verena, Krämer, Tobias J., Luh, Clara, Sebastiani, Anne, Songarj, Phuripong, Steckelings, Ulrike Muscha, Thal, Serge C., Timaru-Kast, Ralph   +9 more
core   +3 more sources