Results 11 to 20 of about 83,177 (340)
Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses [PDF]
Royal Society Open Science, 2019 Humic substances are breakdown products of decaying organic matter that co-extract with proteins from fossils. These substances are difficult to separate from proteins in solution and interfere with analyses of fossil proteomes.
Elena R. Schroeter +3 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Alexandra Ibáñez-Escribano +13 more
doaj +1 more source
Sustainability, 2021 Drawing on the motivation, opportunity and ability (MOA) framework, we investigate the influence of charismatic leadership on salespeople’s service and sales activities—termed service-sales ambidextrous (SSA) behavior, which subsequently turn into ...
Bilal Ahmad +5 more
semanticscholar +1 more source
Proceedings of the Royal Society of London. Series B: Biological Sciences, 2004 Until a few hundred years ago, New Zealand hosted several species of flightless ratite birds, collectively known as the moa. We have used mitochondrial sequence data for Dinornis, the largest of the moa, and new coalescent approaches to estimate its population size prior to human arrival ca. 1000-6000 years BP. We show that, as little as 1000 years ago,
Neil J, Gemmell +2 more
openaire +2 more sources
Computational analyses of mechanism of action (MoA): data, methods and integration
RSC Chemical Biology, 2021 The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the drug discovery process, but it is important in order to rationalise phenotypic findings and to anticipate potential side-effects. Bioinformatic approaches, advances in
Maria-Anna Trapotsi +2 more
semanticscholar +1 more source
Treatment of inflammatory bowel disease from the immunological perspective
Immunological Medicine, 2020 Since 1950, the number of patients with inflammatory bowel disease (IBD) in Japan has been increasing. Recent research data indicate that the pathophysiology of IBD involves abnormalities in disease susceptibility genes, environmental factors and ...
Hiroshi Nakase
doaj +1 more source
Leakage Current Sensor and Neural Network for MOA Monitoring
Computational Intelligence and Neuroscience, 2022 Metal-oxide arrester (MOA) has been widely used in electric power systems. The leakage current monitoring of MOA can not only detect the MOA's running state continuously and intelligently but also reduce the unexpected outage of the equipment, which is ...
Tao He +4 more
semanticscholar +1 more source
Behavior Research Methods, 2021 Performance in everyday tasks, such as driving and sport, requires allocation of attention to task-relevant information and the ability to inhibit task-irrelevant information.
A. Mackenzie +7 more
semanticscholar +1 more source
Mechanism-Informed Language Modeling and Oxygenated 3D Screening Identify Berberine-Enzalutamide Synergy in Prostate Cancer Models. [PDF]
Adv Sci (Weinh)By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Lo CH +15 more
europepmc +2 more sources
MOA-seq identifies shared and unique regions in open chromatin.
, 2021 Comparison of MOA-seq to open chromatin profiling techniques DNS-Seq and ATAC-Seq. (A) Genome-wide distribution of MOA-seq footprints relative to genomic annotations. (B) MOA-seq read coverage (CPM) is non-randomly distributed around genes.
Daniel L. Vera (3175611) +10 more
core +1 more source