Results 251 to 260 of about 138,791 (334)

Unifying pharmacology, systems biology, and regenerative medicine to advance personalized therapies. [PDF]

Front Pharmacol
Martins A.
europepmc   +1 more source

Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide‐susceptible and resistant strains

Pest Management Science, Volume 82, Issue 2, Page 1618-1628, February 2026.
Two small molecules, SACC‐0039590 and SACC‐0428788, killed cattle fever tick, R. microplus, susceptible Deutch strain and pyrethroid resistant Arauquita strain larvae. SACC‐0039590 at 1 mM decreased the reproductive parameters of Deutch females. Abstract BACKGROUND Resistance to acaricides underscores the need for tick control alternatives.
Waleed M. Arafa, Kimberly H. Lohmeyer, Patricia V. Pietrantonio   +2 more
wiley   +1 more source

Herbicide toxicity to Nitrospirillum amazonense: assessing bacterial survival and microbial functionality

Pest Management Science, Volume 82, Issue 2, Page 1842-1852, February 2026.
Herbicides elicit a spectrum of responses in Nitrospirillum amazonense, ranging from the stimulation of metabolic functions (biological nitrogen fixation, IAA production) to significant growth inhibition and acute toxicity. Abstract BACKGROUND Herbicides can exert significant toxicity on nontarget organisms, including plant growth‐promoting bacteria ...
Luana Carolina Gomes Jonck, Patrícia Andrea Monquero, Márcia Maria Rosa Magri, Carina de Fátima Felippe   +3 more
wiley   +1 more source

Integrating MBMA and QSP to Identify Key Covariates and Predict Treatment Outcomes in Relapsed/Refractory Multiple Myeloma

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT This study demonstrates the application of a model based meta analysis (MBMA) framework to characterize the safety and efficacy profiles of therapies in relapsed and refractory multiple myeloma (RRMM). Published clinical trial data were analyzed to evaluate the incidence of Grade ≥ 3 neutropenia and overall response rate (ORR), providing a ...
Zeel Shah, Clifton M. Anderson, Kevin D. McCormick, Celeste Vallejo, William Duncan, Chuanpu Hu, Jian Zhou, Alexander V. Ratushny, Anna G. Kondic   +8 more
wiley   +1 more source

Vulnerability of mineral-organic associations in the rhizosphere. [PDF]

Nat Commun
Bölscher T, Cardon ZG, Garcia Arredondo M, Grand S, Griffen G, Hestrin R, Imboden J, Jamoteau F, Lacroix EM, Pérez Castro S, Persson P, Riley WJ, Keiluweit M.   +12 more
europepmc   +1 more source

Puerto de Cayo Moa

Presenta la costa de la isla con la desembocadura del río Moa y el cayo Moa y su puerto Coordenadas referidas al meridiano de Cádiz. Orientado con media lis Relieve representado por sombreado y de perfil Indica sondas batimétricas e isolíneas de batimetría Señala que los números de la sonda son ...
openaire   +1 more source

A Generalized Minimal PBPK‐PD Model of Bispecific Antibodies: Case Studies and Applications in Drug Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Bispecific antibodies (bsAbs), for which each arm binds a distinct molecular target, are developed to engage soluble and cell surface targets in different therapeutic indications. Three key examples of mechanisms of action (MoA) for bsAbs are (1) immune cell engagers that foster immune cell interactions with target cells, (2) bispecifics that ...
Phillip Spinosa, Louis Joslyn, Saroja Ramanujan, Kapil Gadkar, Iraj Hosseini   +4 more
wiley   +1 more source

An energy aware routing protocol using mayfly optimization (ERPMO) and TDMA scheduling in wireless sensor networks. [PDF]

Sci Rep
Sinduja B, Yaashuwanth C, Prathibanandhi K, Ramesh S.   +3 more
europepmc   +1 more source

Filgotinib Is an Effective and Safe Treatment Option for Difficult‐To‐Treat Ulcerative Colitis: Real‐World Evidence of the Dutch Initiative on Crohn and Colitis (ICC) Registry

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Filgotinib is a preferential Janus kinase 1 (JAK‐1) inhibitor registered for the treatment of ulcerative colitis (UC). Real‐world effectiveness of filgotinib, especially for difficult‐to‐treat (DTT, failure of ≥ 2 prior advanced therapies) patients, has been scarcely reported.
M. R. Naber, A.E van der Meulen, P. W. Voorneveld, S. H. C. Veltkamp, A.A. van Bodegraven, A. Bodelier, Z. Mujagic, M. Pierik, L. M. M. Verleye, M. Duijvestein, D. G. Bouwknegt, M. C. Visschedijk, N. Srivastava, R. L. West, B. Oldenburg, M. Löwenberg, F.D.M. van Schaik, On behalf of the Dutch ICC Registry   +17 more
wiley   +1 more source