Results 31 to 40 of about 124,114 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SECURE MOBILE AGENT TRADER SYSTEM [PDF]

International Journal of Intelligent Computing and Information Sciences, 2016
Mobile agent systems (MASs) that travel autonomously through a computer network in order to perform some computation or gather information on behalf of a human user or an application. business applications. In most applications, the security of mobile
R Hassaan, S Koriem
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Testing Mobile Agents [PDF]

, 2002
For years to come, we can predict an important increase in the use of software systems using mobile code. Those systems give birth to new development problems compared to current distributed systems. In particular, testing for such systems must take into account the mobility of tested processes, which makes it difficult to maintain contact points ...
Mikael Marche, Yves-Marie Quemener, Roland Groz   +2 more
openaire   +1 more source

A mobile agent infrastructure for the mobility support [PDF]

Proceedings of the 2000 ACM symposium on Applied computing - Volume 2, 2000
The mobility of terminals and users is a crucial issue in the open global system represented by the Internet. Supporting terminal and user mobility requires a middleware infrastructure capable of efficiently answering the needs of scalable resource discovery, of security and interoperability, of Quality of Service (QoS) monitoring and adaptation.
Paolo Bellavista, Antonio Corradi, Cesare Stefanelli   +2 more
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

A Mobile Agent-Based System for Server Resource Monitoring

Cybernetics and Information Technologies, 2013
Mobile agent technology has become an important approach for the design and development of distributed systems. Currently, there is little research regarding the efficiency of mobile agent-based monitoring of the server resource.
Tie Zhixin
doaj   +1 more source

Mobile Agent-Based Software Systems Modeling Approaches: A Comparative Study

Journal of Computing and Information Technology, 2016
Mobile agent-based applications are special type of software systems which take the advantages of mobile agents in order to provide a new beneficial paradigm to solve multiple complex problems in several fields and areas such as network management, e ...
Aissam Belghiat, Elhillali Kerkouche, Allaoua Chaoui, Mokhtar Beldjehem   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source