Results 41 to 50 of about 164,111 (261)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Improving Podcast Distribution on Gwanda using PrivHab: a Multiagent Secure Georouting Protocol.

Advances in Distributed Computing and Artificial Intelligence Journal, 2015
We present PrivHab, a multiagent secure georouting protocol that improves podcast distribution on Gwanda, Zimbabwe. PrivHab learns the whereabouts of the nodes of the network to select an itinerary for each agent carrying a piece of data.
Adrián SÁNCHEZ-CARMONA, Sergi ROBLES, Carlos BORREGO   +2 more
doaj   +1 more source

A mobile agent infrastructure for the mobility support [PDF]

Proceedings of the 2000 ACM symposium on Applied computing - Volume 2, 2000
The mobility of terminals and users is a crucial issue in the open global system represented by the Internet. Supporting terminal and user mobility requires a middleware infrastructure capable of efficiently answering the needs of scalable resource discovery, of security and interoperability, of Quality of Service (QoS) monitoring and adaptation.
Paolo Bellavista, Antonio Corradi, Cesare Stefanelli   +2 more
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A Distributed and Collaborative Intelligent System for Medical Diagnosis

Advances in Distributed Computing and Artificial Intelligence Journal, 2013
In this paper, we present a distributed collaborative system assisting physicians in diagnosis when processing medical images. This is a Web-based solution since the different participants and resources are on various sites.
Naoufel KHAYATI, Wided LEJOUAD-CHAARI
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Novel mobile agent dynamic data integrity protection protocol

Tongxin xuebao, 2007
Integrity characteristics of dynamic data was redefined and classified by attacker capability,and then it was analyzed how to protect truncation attack with collusion.After that,a data protection protocol of free-roaming agent was presented.The protocol ...
LI Peng-fei1, QING Si-han2, MA Heng-tai1, DENG Yong1   +3 more
doaj  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source