Results 91 to 100 of about 14,634,052 (312)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Application Mobility

, 2015
Mobility has become an omnipresent part of our modern IT society. Alongside the general taxonomy of mobile users, terminals, sessions, and services, there are also more specialized forms of mobility. Context-Awareness Supported Application Mobility (CASAM) or “Application Mobility” is one such form that is explored in this chapter.
Johansson, Dan, Wiberg, Mikael
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Rater reliability and construct validity of a mobile application for posture analysis

Journal of Physical Therapy Science, 2018
[Purpose] Measurement of posture is important for those with a clinical diagnosis as well as researchers aiming to understand the impact of faulty postures on the development of musculoskeletal disorders.
Kimberly Szucs, Elena V. Donoso Brown
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Risk Assessment Framework for Mobile Apps in Mobile Cloud Computing Environments

Future Internet
Mobile devices (MDs) are used by mobile cloud computing (MCC) customers and by other users because of their portability, robust connectivity, and ability to house and operate third-party applications (apps).
Noah Oghenefego Ogwara, Krassie Petrova, Mee Loong Yang, Stephen G. MacDonell   +3 more
doaj   +1 more source

Mobile Application for Inventory Control in a Minimart

ComTech, 2017
The goal of the research was to design a mobile application of inventory system in a minimart. In an application of using the mobile-based inventory minimart, J2EE system development used Waterfall method with the stages of analysis, design, coding, and
Febriyanti Darnis
doaj   +1 more source

Perancangan dan Evaluasi User Interface Aplikasi Smart Grid Berbasis Mobile Application

Jurnal Nasional Teknik Elektro dan Teknologi Informasi (JNTETI), 2018
Smart grid mobile application is a modernization in the consumption of electric power. Based on current research on smart grid mobile applications, it has investigated to the monitoring function, regulating, and scheduling energy consumption only. In the
E. Susilo, F. D. Wijaya, Rudy Hartanto
semanticscholar   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source