Results 61 to 70 of about 460,385 (314)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
GraphQL or REST for Mobile Applications?
, 2022 Currently, GraphQL has emerged as a query language for developing web APIs that propose to improve several data access problems of RESTful APIs. The present paper aims to study the effects on software quality of APIs developed with REST and GraphQL architectures consumed from mobile applications.
Antonio Quiña-Mera +4 more
openaire +2 more sources
, 2014 This paper aims to present a pilot study of the development of a Location-Based Mobile application to support informal learning in the cultural heritage domain. In this paper, we introduce a prototype of the Mobile Location Based System.
Fallahkhair, Sanaz; id_orcid +6 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Contextual queries express mobile information needs
, 2010 The users of mobile devices increasingly use networked services to address their information needs. Questions asked by mobile users are strongly influenced by contextual factors such as location, conversation and activity.
Nichols, David M. +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Scheme of mobile informatization in electric power enterprise
Dianxin kexue, 2017 The electric power enterprises' mobile information development trend was analyzed,an enterprises' mobile informatization scheme based on enterprise “mobile platform and mobile applications”was put forward,including the overall technical route and the ...
Hualu ZHANG +3 more
doaj +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source