Results 31 to 40 of about 3,582 (240)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of Mobile Phone Game Addiction on Sri Lankan Teenagers: An Exploratory Study

Asian Journal of Education and Social Studies, 2020
Technology has become an essential part of human life and it has significantly changed the behaviors of individuals. One of the popular applications of technology is the smartphone and it has an inseparable relationship with modern teenagers. With the improvement of technology, many teenagers use their mobile phones for playing games.
Karunanayake, D D K S, Perera, R a a R, Vimukthi, N D U   +2 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Gacha Addiction and In-App Purchases: A Study on Genshin Impact Players in Indonesia

Matrik
The purpose of this study was to examine the impact of gacha addiction and good price on the intention to purchase in-app items, with mobile game loyalty as a mediating variable.
Cokki Cokki, Haris Maupa, Wanstum Wanstum, Syarifuddin Sulaiman   +3 more
doaj   +1 more source

Smartphone use and smartphone addiction in middle school students in Korea: Prevalence, social networking service, and game use

Health Psychology Open, 2018
This study aimed to examine smartphone use patterns, smartphone addiction characteristics, and the predictive factors of the smartphone addiction in middle school students in South Korea. According to the Smartphone Addiction Proneness Scale scores, 563 (
Seong-Soo Cha, Bo-Kyung Seo
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Investigating the influence of mobile game addiction on in-app purchase intention in PUBG mobile: the mediating roles of loyalty, negative e-WOM and perceived risk

Cogent Business & Management
This study focuses on in-app purchase intention in Players Unknown Battleground (PUBG) Mobile to examine the relationship between mobile game addiction and in-app purchase intention in PUBG Mobile.
Ronaldo Yolanda Putra, Rakotoarisoa Maminiaina Heritiana Sedera, Rakotoarisoa Maminirina Fenitra   +2 more
doaj   +1 more source

An Overview of the CRoME Lab’s MedSMA℞T Families Intervention for Promoting Opioid Medication Safety among Adolescents and Parents

INNOVATIONS in Pharmacy, 2023
As the opioid epidemic unrelentingly places profound weight on pharmacists, youth, parents, and the nation at large, innovative interventions are critical to prevent potential misuse and untimely death.
Olufunmilola Abraham, Tyler McCarthy
doaj   +1 more source