Results 21 to 30 of about 853 (166)

DIVE: a reference-free statistical approach to diversity-generating and mobile genetic element discovery

Genome Biology, 2023
Diversity-generating and mobile genetic elements are key to microbial and viral evolution and can result in evolutionary leaps. State-of-the-art algorithms to detect these elements have limitations.
Jordi Abante, Peter L. Wang, Julia Salzman   +2 more
doaj   +1 more source

Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms

Nature Communications, 2022
SCCmec is a large mobile genetic element that confers resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus. Here, the authors show that biofilm growth conditions enhance the efficiency of natural transformation in S.
Mais Maree, Le Thuy Thi Nguyen, Ryosuke L. Ohniwa, Masato Higashide, Tarek Msadek, Kazuya Morikawa   +5 more
doaj   +1 more source

MGEs as the MVPs of Partner Quality Variation in Legume-Rhizobium Symbiosis

mBio, 2022
Despite decades of research, we are only just beginning to understand the forces maintaining variation in the nitrogen-fixing symbiosis between rhizobial bacteria and leguminous plants. In their recent work, Alexandra Weisberg and colleagues use genomics
Katy D. Heath, Rebecca T. Batstone, Mario Cerón Romero, John G. McMullen   +3 more
doaj   +1 more source

Regulation of solvent tolerance in Pseudomonas putida S12 mediated by mobile elements

Microbial Biotechnology, 2017
Summary Organic solvent‐tolerant bacteria are outstanding and versatile hosts for the bio‐based production of a broad range of generally toxic aromatic compounds.
Rohola Hosseini, Jannis Kuepper, Sebastian Koebbing, Lars M. Blank, Nick Wierckx, Johannes H. deWinde   +5 more
doaj   +1 more source

A Virulence Associated Siderophore Importer Reduces Antimicrobial Susceptibility of Klebsiella pneumoniae

Frontiers in Microbiology, 2021
The accessory genomes of many pathogenic bacteria include ABC transporters that scavenge metal by siderophore uptake and ABC transporters that contribute to antimicrobial resistance by multidrug efflux.
Robeena Farzand, Robeena Farzand, Kumar Rajakumar, Michael R. Barer, Primrose P. E. Freestone, Galina V. Mukamolova, Marco R. Oggioni, Helen M. O’Hare, Helen M. O’Hare   +8 more
doaj   +1 more source

The HipAB Toxin–Antitoxin System Stabilizes a Composite Genomic Island in Shewanella putrefaciens CN-32

Frontiers in Microbiology, 2022
Composite genomic islands (GIs) are useful models for studying GI evolution if they can revert into the previous components. In this study, CGI48—a 48,135-bp native composite GI that carries GI21, whose homologies specifically integrated in the conserved
Yi Zhao, Weiquan Wang, Weiquan Wang, Weiquan Wang, Jianyun Yao, Jianyun Yao, Xiaoxue Wang, Xiaoxue Wang, Xiaoxue Wang, Dong Liu, Pengxia Wang, Pengxia Wang, Pengxia Wang   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Antimicrobial resistome and mobilome in the urban river affected by combined sewer overflows and wastewater treatment effluent

Journal of Water and Health, 2023
The dissemination of antimicrobial resistance in the environment is an emerging global health problem. Wastewater treatment effluent and combined sewer overflows (CSOs) are major sources of antimicrobial resistance in urban rivers.
Muhammad Adnan Sabar, Than Van Huy, Yoshinori Sugie, Hiroyuki Wada, Bo Zhao, Norihisa Matsuura, Masaru Ihara, Toru Watanabe, Hiroaki Tanaka, Ryo Honda   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Association of ISVsa3 with Multidrug Resistance in Salmonella enterica Isolates from Cattle (Bos taurus)

Microorganisms, 2023
Salmonella enterica is, globally, an important cause of human illness with beef being a significant attributable source. In the human patient, systemic Salmonella infection requires antibiotic therapy, and when strains are multidrug resistant (MDR), no ...
Gentry L. Lewis, Robert J. Fenton, Etsuko N. Moriyama, John Dustin Loy, Rodney A. Moxley   +4 more
doaj   +1 more source