An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
The Uganda - Democratic Republic of the Congo cross-border collaboration for Bundibugyo Ebola response: A new model for African health security, sovereignty and solidarity. [PDF]
J Public Health AfrBosa HK +17 more
europepmc +1 more source
Coexistence of AI Generations: Lessons from Mobile Network Evolution and Their Security Implications
A B Nataraju +3 more
openalex +1 more source
Advanced Science, EarlyView.A low‐temperature synthesis method of single‐crystalline NCA was successfully achieved by Sn doping, employing the same synthetic conditions as its polycrystalline counterparts. This synthesis was conducted at a temperature that was 150 °C lower than that required for synthesizing single‐crystalline NCA without Sn doping.
Guomeng Xie +4 more
wiley +1 more source
A review of older adults' acceptance of health monitoring tools: application status, theoretical acceptance models, and user-related and context-level influencing factors. [PDF]
Front Public HealthZhang Q, Zhang Y.
europepmc +1 more source
Advanced Science, EarlyView.A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li +4 more
wiley +1 more source
AI-driven financial risk management in complex mobile economies: a contextual-technology fit and security reassurance model. [PDF]
Front Artif IntellJiang Z, Jiang X.
europepmc +1 more source
Advanced Science, EarlyView.The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng +10 more
wiley +1 more source
The "Information Paradox" in crime prevention: how spatial context and age moderate the impact of safety advisories on residents' perception of safety. [PDF]
Front Public HealthWang Z.
europepmc +1 more source
A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Advanced Science, EarlyView.Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source