Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
An efficient data collection path planning scheme for wireless sensor networks with mobile sinks
Wireless sensor networks with mobile sinks enable a mobile device to move into the sensing area for the purpose of collecting the sensing data. Mobile sinks increase the flexibility and convenience of data gathering in such systems.
Jau-Yang Chang +4 more
doaj +1 more source
Sensing Eating Events in Context: A Smartphone-Only Approach
While the task of automatically detecting eating events has been examined in prior work using various wearable devices, the use of smartphones as standalone devices to infer eating events remains an open issue. This paper proposes a framework that infers
Wageesha Bangamuarachchi +5 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
CENTURION: Incentivizing Multi-Requester Mobile Crowd Sensing
The recent proliferation of increasingly capable mobile devices has given rise to mobile crowd sensing (MCS) systems that outsource the collection of sensory data to a crowd of participating workers that carry various mobile devices.
Jin, Haiming, Nahrstedt, Klara, Su, Lu
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Investment and Pricing with Spectrum Uncertainty: A Cognitive Operator's Perspective
This paper studies the optimal investment and pricing decisions of a cognitive mobile virtual network operator (C-MVNO) under spectrum supply uncertainty.
Duan, Lingjie +2 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Participants Ranking Algorithm for Crowdsensing in Mobile Communication
As mobile technology is becoming more advance, the uses of this technology is increasing day by day. The mobile phone is used by everyone and it became the necessity of life. Today, smart devices are flooding the internet with data that are everywhere and
Tariq Ali +5 more
doaj +1 more source

