Results 41 to 50 of about 1,026,389 (317)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

More than a meeting: identifying the needs of the community-based seniors’ services sector as providers of health promotion services

BMC Research Notes, 2021
Objective Many economically developed countries have seen a decline in publicly funded community programming. Within this context, community-based seniors’ service (CBSS) organizations have been increasingly tasked to deliver programs to support the ...
Catherine E. Tong, Joanie Sims-Gould, Sarah Lusina-Furst, Heather McKay   +3 more
doaj   +1 more source

News: Mobiles, Mobilities and Their Meeting Points [PDF]

Digital Journalism, 2020
As both news and audiences are increasingly mobile, this introduction calls for intensified research into mobility as a core characteristic of journalism.
Andrew Duffy, Rich Ling, Nuri Kim, Edson Tandoc, Oscar Westlund   +4 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Modeling and Analysis of Mixed Traffic Networks with Human-Driven and Autonomous Vehicles

Chinese Journal of Mechanical Engineering
The emergence of connected and automated vehicles (CAV) indicates improved traffic mobility in future traffic transportation systems. This study addresses the research gap in macroscopic traffic modeling of mixed traffic networks where CAV and human ...
Qing Xu, Chaoyi Chen, Xueyang Chang, Dongpu Cao, Mengchi Cai, Jiawei Wang, Keqiang Li, Jianqiang Wang   +7 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Hierarchical reinforcement learning for self‐driving decision‐making without reliance on labelled driving data

IET Intelligent Transport Systems, 2020
Decision making for self‐driving cars is usually tackled by manually encoding rules from drivers’ behaviours or imitating drivers’ manipulation using supervised learning techniques.
Jingliang Duan, Shengbo Eben Li, Yang Guan, Qi Sun, Bo Cheng   +4 more
doaj   +1 more source

Climate mobilities: migration, im/mobilities and mobility regimes in a changing climate [PDF]

, 2022
Ingrid Boas, Hanne Wiegel, Carol Farbotko, Jeroen Warner, Mimí Sheller   +4 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Predicting driving comfort in autonomous vehicles using road information and multi-head attention models

Nature Communications
Driving comfort is a crucial consideration in the automotive industry. In the realm of autonomous driving, comfort has always been a factor that requires continuous improvement.
Zhengxian Chen, Yuqi Liu, Wenjie Ni, Han Hai, Chaosheng Huang, Boyang Xu, Zihan Ling, Yang Shen, Wenhao Yu, Huanan Wang, Jun Li   +10 more
doaj   +1 more source