Results 141 to 150 of about 1,454,061 (346)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Properties, Production, and Recycling of Regenerated Cellulose Fibers: Special Medical Applications
Journal of Functional BiomaterialsRegenerated cellulose fibers are a highly adaptable biomaterial with numerous medical applications owing to their inherent biocompatibility, biodegradability, and robust mechanical properties.
Sandra Varnaitė-Žuravliova +1 more
doaj +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Sound Radiation Analysis and Noise Reduction Design of Railway Wheel
机车电传动, 2018 The wheel radiation noise is an important contributor of railway noise. Based on the acoustic simulation and experimental techniques, this paper analyzed the radiation noise characteristics of a wheel, and designed a noise reduction wheel combined with ...
ZHA Guotao +4 more
doaj
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
机车电传动, 2017 The rigid-flexible coupling model of axle gear case in tunnel traction locomotive which included the flexible axle and case body was established using Romax, Inventor and Hypermesh software.
LIAN Zhenhong, YANG Zhonglei
doaj
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source