Results 151 to 160 of about 2,484,152 (338)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Experimental Investigation of the Cross-Sensitivity and Size Effects of Polyvinylidene Fluoride Film Sensors on Modal Testing [PDF]
, 2012 Kuo‐Chih Chuang +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Fracture and Structural IntegrityDamage detection in composite materials is crucial for ensuring the safety and reliability of engineering structures. Conventional methods often face challenges in accurately identifying damage in plate-like structures, particularly in scenarios ...
Saeesh Verenkar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Properties, Production, and Recycling of Regenerated Cellulose Fibers: Special Medical Applications
Journal of Functional BiomaterialsRegenerated cellulose fibers are a highly adaptable biomaterial with numerous medical applications owing to their inherent biocompatibility, biodegradability, and robust mechanical properties.
Sandra Varnaitė-Žuravliova +1 more
doaj +1 more source
The comparisons of different therapeutic modalities for idiopathic achalasia
, 2022 Sz‐Iuan Shiu +3 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Telisik Perlakuan Teori Entitas dalam Usaha Mikro, Kecil dan Menengah (UMKM)
Jurnal Akuntansi Multiparadigma, 2013 Various challenges and obstacles still occur in SMEs development in Indonesia. One of them is the behavior of SMEs owners who often do not separate personal finance and business capital.
Dian Purnama Sari
doaj
Estimating the VLF modal interference distance using the South America VLF Network (SAVNET) [PDF]
, 2014 Jorge Samanes +3 more
openalex +1 more source