Results 91 to 100 of about 4,075,278 (310)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Modal Parameter Identification and Damage Localization of Composite Helicopter Rotor Blades Based on AR/PR Identification

International Journal of Aerospace Engineering
The structural characteristics and application background of helicopters determine that the primary dynamic components work in environments with high cyclic amplitude and low-stress vibration fatigue load.
Zefeng Wang, Yuhan Sun, Jie Li, Zhiguang Song   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Modal Identification and Finite Element Model Updating of Flexible Photovoltaic Support Structures Using Multi-Sensor Data

Applied Sciences
Flexible photovoltaic (PV) support structures are widely used due to their large span, high land-use efficiency, low construction cost, and short construction periods.
Mingfeng Huang, Chen Yang, Kang Cai, Xianzhe Li   +3 more
doaj   +1 more source

Modal identification of a boundary input in the two-dimensional inverse heat conduction problem

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2018
A method for the approximate solution of a two-dimensional inverse boundary heat conduction problem on a compact set of continuous and continuously differentiable functions is proposed.
Edgar Ya Rapoport, Anna N Diligenskaya
doaj   +1 more source

OUTPUT-ONLY MODAL IDENTIFICATION OF TENSEGRITY STRUCTURES

Engineering Structures and Technologies, 2016
Tensegrity systems are a special class of spatial reticulated structures that are composed of struts in compression and cables in tension. In this paper, the performance of stochastic subspace algorithms for modal identification of complex tensegrity systems is investigated.
Attig, Miniar, Abdelghani, Maher, Kahla, Nabil ben   +2 more
openaire   +4 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Optimization and engineering verification of excitation scheme for aircraft ground vibration test

Hangkong gongcheng jinzhan
Ground vibration test is an important part of aircraft model development and strength verification. In aircraft ground vibration test，an appropriate excitation scheme can significantly shorten the test's period and improve the accuracy of mode ...
CHEN Haoyu, WANG Binwen, SONG Qiaozhi, LI Xiaodong   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source