Results 81 to 90 of about 2,942,391 (249)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Modal identification of a boundary input in the two-dimensional inverse heat conduction problem

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2018
A method for the approximate solution of a two-dimensional inverse boundary heat conduction problem on a compact set of continuous and continuously differentiable functions is proposed.
Edgar Ya Rapoport, Anna N Diligenskaya
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Broadband Acoustic Modal Identification by Combined Sensor Array Measurements

Acoustics
This paper proposes a synchronous measurement method for broadband acoustic modal identification based on a combined microphone array, which is capable of overcoming the acoustic modal aliasing issue arising from a limited number of microphones.
Kunbo Xu, Dongjun Liu, Zekai Zong, Chenzhe Xiang, Weiyang Qiao, Liang Yu   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Estudo de comportamento dinamico de semi-eixo homocinetico com o uso de analise modal [PDF]

, 1994
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoDevido ao constante avanço tecnológico da indústria automobilística, o desempenho vibratório de componentes veiculares atualmente ocupa destacada posição no aspecto de ...
Kniest, Rodrigo Rihl
core  

On the Development of an AI-Based Tool to Assess the Instantaneous Modal Properties of Nonlinear SDOF Systems

Applied Sciences
In this article, a data-driven algorithm is developed to assess the natural frequency and damping ratio of a nonlinear oscillating single-degree-of-freedom (SDOF) system.
Alvaro Iglesias-Pordomingo, Guillermo Fernandez, Alvaro Magdaleno, Antolin Lorenzana   +3 more
doaj   +1 more source

Development and implementation of a laser system for dynamic characterization and displacement measurement of civil structures

Revista Facultad de Ingeniería Universidad de Antioquia, 2012
Instrumentation and vibration monitoring of civil structures has gained importance during the last decades due to potential applications in modal identification and structural health monitoring.
Jean Michel Franco, Daniel Gómez, Jorge Hernán Murcia, Peter Thomson, Johannio Marulanda   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source