Results 121 to 130 of about 21,974 (265)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Identification of the modal masses of an UAV structure in operational environment

, 2015
In the framework of Operational Modal Analysis, several methods have been developed to estimate the modal parameters, that is natural frequencies, damping ratios, and mode shapes of a structure in its operative conditions.
Arras, M., Coppotelli, G., Cardinale, M. S.   +2 more
core  

Modal parameters of a rotating multiple-disk-shaft system from simulated frequency response data

Applied and Computational Mechanics, 2014
Modal parameters of a rotating multiple disk-shaft system are estimated in Multiple Input/Multiple Output (MIMO) scheme. The response at multiple output degrees of freedom (dofs) and excitations at multiple input (reference) dofs are related through the ...
Khader N.
doaj  

Structural Modal Time Domain Identification Method Based on the Bayesian Uncertain Quantification

Applied Sciences
Based on the Bayesian framework, a time domain method is proposed for the uncertain quantification of structural modal identification. First, a theoretical prediction model is constructed from the state space model in modal space and then transformed ...
Yaozong Pan, Yan Zhao
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The morphological and semantic classification of 'evidentials' and modal verbs in German : the perfect(ive) catalyst

, 2013
This paper draws a link between the typological phenomenon of the paradigmatically supported evidentiality evoked by perfect and/or perfectivity and the equally epistemic system of modal verbs in German.
Abraham, Werner
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Modal parameters evaluation of a structure when adding constraints

, 1997
In the present paper the problem of determining the new modal parameters of a structure when subjected to additional constraints is considered. The aim is to avoid performing a new modal analysis when a structure is modified by adding constraints.
Fregolent, A, FREGOLENT, Annalisa, Fregolent, A., P. Salvini, SALVINI, PIETRO, Salvini, P   +5 more
core  

Identification of characteristic parameters of layered structures using modal parameters

Mechanical Engineering Journal
In this study, we present a method for determining parameters that are essential for evaluating the health of layered structures. This method uses modal parameters to identify characteristic parameters that can accurately reproduce the measured modal ...
Daiki TAJIRI, Shozo KAWAMURA
doaj   +1 more source