Results 101 to 110 of about 505,512 (306)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Sensors, 2013 We experimentally characterized a birefringent side-hole microstructured fiber in the visible wavelength region. The spectral dependence of the group and phase modal birefringence was measured using the methods of spectral interferometry. The phase modal
Waclaw Urbańczyk +6 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Comparison of experimental rotor damping data-reduction techniques [PDF]
The ability of existing data reduction techniques to determine frequency and damping from transient time-history records was evaluated. Analog data records representative of small-scale helicopter aeroelastic stability tests were analyzed.
Warmbrodt, William
core +1 more source
Two-step Bayesian Structure Health Monitoring Approach for IASC-ASCE Phase II Simulated and Experimental Benchmark Studies [PDF]
, 2003 This report uses a two-step probabilistic structural health monitoring approach to analyze the Phase II simulated and experimental benchmark studies sponsored by the IASC-ASCE Task Group on Structural Health Monitoring.
Beck, James L., Ching, Jianye
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
THE STUDY OF MODAL VERBS FROM A PEDAGOGICAL PERSPECTIVE: AN ANALYSIS OF TEXTBOOKS AND GRAMMARS
Revista de Lingüística y Lenguas Aplicadas, 2007 This paper shows how the indiscriminate combination of the form-function criterion in the traditional presentation of modal verbs brings more confusion than light to the subject due mostly to the fact that the grammatical simplicity of modal verbs ...
María Jesús Sánchez +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Modal properties of the flexural vibrating package of rods linked by spacer grids
Applied and Computational Mechanics, 2011 The paper deals with the modelling and modal analysis of the large package of identical parallel rods linked by transverse springs (spacer grids) placed on several level spacings.
Zeman V., Hlaváč Z.
doaj
Heuristic Kernel Density Estimator for Modal‑Proximity Data
Shuju Caiji Yu ChuliDifferent from the classical probability density estimator construction strategies based on the Parzen window method， we propose a heuristic kernel density estimator （HKDE） based on nearest neighbor error measurement function， to improve the accuracy of ...
HE Yulin +4 more
doaj +1 more source