Results 111 to 120 of about 505,512 (306)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Democracy as a Modally Demanding Value [PDF]

Noûs, 2013
Imperialism seems to be deeply antithetical to democracy. Yet, at least one form of imperialism what I call hands-off imperialism seems to be perfectly compatible with the kind of self-governance commonly thought to be the hallmark of democracy. The solution to this puzzle is to recognize that democracy involves more than self-governance.
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Simplified Frequency Estimation of Prefabricated Electric Poles Through Regression-Based Modal Analysis

Applied Sciences
Prefabricated construction elements are widely used in both large- and small-scale projects, serving structural and infrastructural purposes. One notable application is in power transmission poles, which ensure the safe and efficient delivery of ...
Hakan Erkek, Ibrahim Karataş, Doğucan Resuloğulları, Emriye Çınar Resuloğullari, Şahin Tolga Güvel   +4 more
doaj   +1 more source

Impacts on modal choices of new generation freights terminals [PDF]

Increasing pollution, congestion of roads and worries about the spatial and environmental impacts of road transports have promoted the idea of transferring part of freight transportation from roads to railways and waterways.
B. Jourquin, L. Demilie, Michel Beuthe
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modal Parameter Recursive Estimation of Concrete Arch Dams under Seismic Loading Using an Adaptive Recursive Subspace Method

Sensors
Modal parameter estimation is crucial in vibration-based damage detection and deserves increased attention and investigation. Concrete arch dams are prone to damage during severe seismic events, leading to alterations in their structural dynamic ...
Xinyi Zhu, Jianchun Qiu, Yanxin Xu, Xingqiao Chen, Pengcheng Xu, Xin Wu, Shaolong Guo, Jicheng Zhao, Jiale Lin   +8 more
doaj   +1 more source

Nonmodal Growth of TravelingWaves on Blunt Cones at Hypersonic Speeds [PDF]

The existing database of transition measurements in hypersonic ground facilities has established that, as the nosetip bluntness is increased, the onset of boundary layer transition over a circular cone at zero angle of attack shifts downstream.
Choudhari, Meelan M., Jewell, Joseph S., Kimmel, Roger L., Paredes, Pedro   +3 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Mechanism and Regularity of Wet Modes in a Highly Integrated Marine Magnetic Levitation Pump Rotor Under Confined Water Conditions

Journal of Marine Science and Engineering
Designed to mitigate the significant low-frequency vibration and noise inherent in conventional marine centrifugal pump systems, the magnetic levitation pump constitutes a novel form of centrifugal pump employing active magnetic bearing technology. While
Shiyu Fang, Yingsan Wei, Gong Cheng, Qi Liu, Xingyu Wu   +4 more
doaj   +1 more source