Results 11 to 20 of about 567,731 (269)

Machine learning to estimate the local quality of protein crystal structures

Scientific Reports, 2021
Low-resolution electron density maps can pose a major obstacle in the determination and use of protein structures. Herein, we describe a novel method, called quality assessment based on an electron density map (QAEmap), which evaluates local protein ...
Ikuko Miyaguchi, Miwa Sato, Akiko Kashima, Hiroyuki Nakagawa, Yuichi Kokabu, Biao Ma, Shigeyuki Matsumoto, Atsushi Tokuhisa, Masateru Ohta, Mitsunori Ikeguchi   +9 more
doaj   +1 more source

Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities

Scientific Reports, 2017
Single domain antibodies (sdAbs), made of natural single variable regions of camelid or cartilaginous fish antibodies, or unpaired variable regions of mouse or human IgGs, are some of the more promising biologic modalities.
Naoya Shinozaki, Ryuji Hashimoto, Kiichi Fukui, Susumu Uchiyama   +3 more
doaj   +1 more source

Valuation Сomponent of Metaphor UP vs. DOWN in German Political Cartoon

RUDN Journal of Language Studies, Semiotics and Semantics, 2021
In German political cartoon the metaphor UP vs. DOWN introduces oppositions GOOD vs. BAD, MORE vs. LESS, UNREALIZABLE vs. PRACTICABLE. The paper describes their valuation components accenting the positive or negative sign of oppositions and its base in ...
Galina L. Denisova
doaj   +1 more source

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

Frontiers in Immunology, 2020
Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F, have been shown to be functionally dysregulated in certain human ...
Ralph Adams, Asher Maroof, Terry Baker, Alastair D. G. Lawson, Ruth Oliver, Ross Paveley, Steve Rapecki, Stevan Shaw, Pavan Vajjah, Shauna West, Meryn Griffiths   +10 more
doaj   +1 more source

Ex-Vivo Human-Sized Organ Machine Perfusion: A Systematic Review on the Added Value of Medical Imaging for Organ Condition Assessment

Transplant International
Machine perfused ex-vivo organs offer an excellent experimental platform, e.g., for studying organ physiology and for conducting pre-clinical trials for drug delivery. One main challenge in machine perfusion is the accurate assessment of organ condition.
Jan L. Van Der Hoek, Marleen E. Krommendijk, Srirang Manohar, Jutta Arens, Erik Groot Jebbink   +4 more
doaj   +1 more source

Spatially compounded plane wave imaging using a laser-induced ultrasound source

Photoacoustics, 2020
This work presents spatially compounded plane wave imaging using a laser-induced ultrasound source. The plane wave source consisted of a 30 μm thick film of carbon black-doped PDMS cured on a 100 μm thick polyester substrate and presented a rectangular ...
David Thompson, Damien Gasteau, Srirang Manohar   +2 more
doaj   +1 more source

Modal auxiliary verb constructions in East African Bantu languages

Journal of African Languages and Literatures, 2022
In this article we offer an overview of the use of modal auxiliary verb constructions in East African Bantu (encompassing languages spoken from eastern Congo in the north-west to northern Mozambique in the south-east; viz.
Rasmus Bernander, Maud Devos, Hannah Gibson   +2 more
doaj   +1 more source

Polygrammaticalization of the verb "xāstan" in Persian Language A cognitive study in the framework of basic event schemas [PDF]

̒Ilm-i Zabān, 2020
Polygrammaticalization is a type of multiple development where a single form develops distinct grammatical functions in different constructions. The verb ‘xāstan’ is an instance of this phenomenon which conceptualizes specific notions of tense, aspect ...
Morteza Dastlan
doaj   +1 more source

Modality

, 2014
(Abstract to follow)
Marije A. J. Baalman, Till Bovermann, Alberto de Campo, Miguel Negrão   +3 more
openaire   +2 more sources

Female levator ani muscle damage assessment in supine and upright position

Scientific Reports
There is damage in the pelvic floor only visible in upright imaging. This damage have not been yet studied. The aim of this research is to assess the difference in levator ani muscle (LAM) damage in supine and upright position by means of MRI scans ...
Irina de Alba Alvarez, Annemarie van der Steen, Anique T.M. Grob, Frieda van den Noort   +3 more
doaj   +1 more source