Results 31 to 40 of about 721,781 (268)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Individual Differences in Signal Perception for Takeover Request in Autonomous Driving
Applied Sciences, 2023 In the context of partial autonomy, where autonomous vehicles and humans share control of the vehicle, bringing out-of-the-loop drivers back into the loop is a significant challenge.
Okkeun Lee, Hyunmin Kang
doaj +1 more source
A novel multi-modal depression detection approach based on mobile crowd sensing and task-based mechanisms [PDF]
, 2022 Ravi Prasad Thati +3 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
On Actuality Entailments, Causation, and Telicity in Balkar
Languages, 2023 This paper presents a study of actuality entailments in Balkar (a dialect of Karachay-Balkar, Turkic). The study focuses on the deontic and causal meanings of four morphemes: two suffixes (the causative suffix and the suffix -al (‘can/may’)) and two ...
Dmitry Privoznov
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Telehealth and people with disabilities in the United Kingdom: a scoping review
Frontiers in Public HealthIntroductionTelehealth, also sometimes known as telemedicine, is the use of communication technologies to deliver healthcare remotely, has become increasingly vital, particularly since the COVID-19 pandemic. While telehealth can improve healthcare access,
Mezhen Ko +7 more
doaj +1 more source
Sequence-of-tense and the features of finite tenses
Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2015 Sequence-of-tense (SOT) is often described as a (past) tense verb form that does not correspond to a semantically interpretable tense. Since SOT clauses behave in other respects like finite clauses, the question arises as to whether the syntactic ...
Karen Zagona
doaj +1 more source
Pharmaceutics, 2023 The discovery and development of first-in-class (FIC) drugs are becoming increasingly important due to increasing reimbursement pressure and personalized medication.
Ryo Okuyama
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source