Results 61 to 70 of about 7,745 (255)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Reconfigurable Three-Mode Converter for Flexible Mode Division Multiplexing Optical Networks

IEEE Photonics Journal
Mode converters with reconfigurable functionality are essential for enabling flexible operation in modern mode division multiplexing (MDM) technology-based optical networks. In this paper, we propose a novel reconfigurable three-mode converter capable of
Mohammad Shuhrawardy, Kazi Tanvir Ahmmed, Chi Hung Yeung, Wei Jin, Liangjun He, Binghui Li, Hau Ping Chan   +6 more
doaj   +1 more source

Simultaneous Wavelength- and Mode-Division (De)multiplexing for High-Capacity On-Chip Data Transmission Link

IEEE Photonics Journal, 2016
We present designs of wavelength-division-multiplexing (WDM) and mode-division-multiplexing (MDM) optical links using mode de/multiplexers (DE/MUXs) based on multimode interference (MMI) couplers with a tilt joint as a phase shifter.
Liangshun Han, Song Liang, Junjie Xu, Lijun Qiao, Hongliang Zhu, Wei Wang   +5 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

On-chip data exchange for mode division multiplexed signals

Optics Express, 2016
Data exchange is an important function for flexible optical network, and it has been extensively investigated for the time and wavelength domains. The mode division multiplexing (MDM) has been proposed to further increase the transmission capacity by carrying information on different modes with only single wavelength carrier.
Mengyuan, Ye, Yu, Yu, Chunlei, Sun, Xinliang, Zhang   +3 more
openaire   +2 more sources

Empowering high-dimensional optical fiber communications with integrated photonic processors

Nature Communications
Mode-division multiplexing (MDM) in optical fibers enables multichannel capabilities for various applications, including data transmission, quantum networks, imaging, and sensing.
Kaihang Lu, Zengqi Chen, Hao Chen, Wu Zhou, Zunyue Zhang, Hon Ki Tsang, Yeyu Tong   +6 more
doaj   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Characteristics of Guided Acoustic Wave Brillouin Scattering in Uncoupled Seven-core Few-mode Fiber

Guangtongxin yanjiu, 2023
The Guided Acoustic Wave Brillouin Scattering (GAWBS) in fibers will be excited at a low optical power level, which can cause large impairments on high-capacity spatial division multiplexing optical fiber communication, digital coherent transmission and ...
ZHANG Ze-lin, ZHOU Hui, QIN Yu, XU Wei-wei, JIANG Xin-li, CAO Shan-shan, XIE Shu-hong, SHEN Yi-chun, XIAO Li-min   +8 more
doaj  

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Optical Networking Beyond WDM

IEEE Photonics Journal, 2012
Wavelength-division multiplexing (WDM) has been the workhorse of data networks, accommodating exponential traffic growth for two decades. Recently, however, progress in WDM capacity research has markedly slowed down as experiments are closely approaching
Peter J. Winzer
doaj   +1 more source