Results 171 to 180 of about 3,395,799 (300)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Stretched-Pulse Mode-Locked Laser Using Post-Cavity Stretching for Ultrahigh-Speed OCT. [PDF]

IEEE Photonics Technol Lett
Joo J, Cho S, Vakoc BJ, Oh WY.
europepmc   +1 more source

Hierarchical Physical‐Cyber Encryption via Metasurface‐Encoded Holographic Keys

Advanced Science, EarlyView.
ABSTRACT Physical‐layer encryption based on metasurfaces has emerged as a promising alternative to conventional algorithmic cryptography by embedding security into physical processes. However, most existing metasurface‐based encryption schemes operate within single‐stage or static frameworks, where correct physical illumination directly reveals the ...
Zhen Liu, Changhong Dai, Wei Zhu, Ruisheng Yang, Bohan Zhang, Lei Zhang, Bobo Du, Shengxiang Wang, Guangwei Hu   +8 more
wiley   +1 more source

Generation of compressed optical pulses beyond 160 GHz based on two injection-locked CW lasers

Two CW signals separated by either 160GHz or 200GHz are phase locked to each other and combined together forming a highly stable pulsed seed for a nonlinear compressor based on four-wave mixing in ...
Parmigiani, F., Slavík, R., Petropoulos, P., Gorman, J.O., Richardson, D.J., Phelan, R.   +5 more
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Phase-stable Doppler OCT at 19 MHz using a stretched-pulse mode-locked laser. [PDF]

Biomed Opt Express, 2018
Tozburun S, Blatter C, Siddiqui M, Meijer EFJ, Vakoc BJ.   +4 more
europepmc   +1 more source

Millisecond Spin Relaxation Times of Distinct Electron and Hole Subensembles in MAxFA1−xPbI3 Perovskite Crystals

Advanced Science, EarlyView.
Mixed‐cation MAx${\rm MA}_x$ FA1−x${\rm FA}_{1-x}$ PbI3${\rm PbI}_3$ perovskite crystals reveal multiple discrete electron and hole spin subensembles associated with distinct localization environments. Optically detected magnetic resonance combined with resonant spin inertia uncovers carriers spin relaxation times reaching 2 ms and identifies nuclear ...
Rongrong Hu, Sergey R. Meliakov, Dmitri R. Yakovlev, Bekir Turedi, Maksym V. Kovalenko, Manfred Bayer, Vasilii V. Belykh   +6 more
wiley   +1 more source

Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography. [PDF]

Biomed Opt Express, 2018
Pfeiffer T, Petermann M, Draxinger W, Jirauschek C, Huber R.   +4 more
europepmc   +1 more source

Terahertz‐Nanoscale Visualization of the Microscopic Spin‐Charge Architecture of Colossal Magnetoresistive Switching

Advanced Science, EarlyView.
This study employs cryogenic magneto‐terahertz nanoscopy to reveal the real‐space electrodynamics of the colossal magnetoresistance transition. By capturing the terahertz electrodynamic evolution of field‐driven spin switching, the work unveils the dissipative dynamics of emergent metallic states, providing a high‐frequency view of coupled spin‐charge ...
Samuel Haeuser, Randall K. Chan, Richard H. J. Kim, Joong‐Mok Park, Martin Mootz, Thomas Koschny, Jigang Wang   +6 more
wiley   +1 more source

Sub-Nanosecond Single Mode-Locking Pulse Generation in an Idler-Resonant Intracavity KTA Optical Parametric Oscillator Driven by a Dual-Loss-Modulated Q-Switched and Mode-Locked Laser with an Acousto-Optic Modulator and MoWS₂. [PDF]

Nanomaterials (Basel)
Han C, Chu H, Feng T, Zhao S, Li D, Zhang H, Zhao J, Huang W.   +7 more
europepmc   +1 more source