Results 51 to 60 of about 34,535 (289)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Stable operation of a synchronously pumped colliding-pulse mode-locked ring dye laser [PDF]

, 1984
Pulses of 100-fsec duration are obtained by synchronous pumping of a colliding-pulse ring dye laser with a mode-locked Ar+-ion laser. Stable operation of the synchronously pumped colliding-pulse mode-locked laser over hours was obtained by a suitable ...
Leonhardt, R., Nuss, M. C., Zinth, Wolfgang   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dispersion-Managed Tm-Ho Co-Doped Ultrashort Pulse Fiber Laser Using Single-Walled Carbon Nanotube and Spectral Filter

Applied Sciences, 2022
In this paper, we have demonstrated a dispersion-managed, high-power, Tm-Ho co-doped ultrashort pulse fiber laser using a single walled carbon nanotube (SWNT) dispersed in polyimide film.
Keisuke Fukazawa, Ying Zhou, Shotaro Kitajima, Takeshi Saito, Youichi Sakakibara, Norihiko Nishizawa   +5 more
doaj   +1 more source

Mode Locking At and Below the CW Threshold

, 2013
We explore experimentally a new regime of operation for mode locking in a Ti:Sapphire laser with enhanced Kerr nonlinearity, where the threshold for pulsed operation is lowered below the threshold for continuous-wave (CW) operation.
Pe'er, Avi, Yefet, Shai
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Absorber-Free Mode-Locking of a Hybrid Integrated Diode Laser at Sub-GHz Repetition Rate

Photonics
We demonstrate absorber-free passive and hybrid mode-locking at sub-GHz repetition rates, using a hybrid integrated extended cavity diode laser operating near 1550 nm.
Anzal Memon, Albert van Rees, Jesse Mak, Youwen Fan, Peter J. M. van der Slot, Hubertus M. J. Bastiaens, Klaus-Jochen Boller   +6 more
doaj   +1 more source

Mode locking of vortex matter driven through mesoscopic channels [PDF]

, 2002
We investigated the driven dynamics of vortices confined to mesoscopic flow channels by means of a dc-rf interference technique. The observed mode-locking steps in the $IV$-curves provide detailed information on how the number of rows and lattice ...
A. Kolton, A. M. Troyanovski, A. Pruymboom, A. Schmid, A. T. Fiory, G. Grüner, J. M. Harris, K. Harada, L. Van Look, M. H. Theunissen, N. Kokubo, O. Daldini, P. H. Kes, P. H. Kes, P. Martinoli, P. Martinoli, R. Besseling, R. Besseling, R. E. Thorne, S. Bhattacharya, V. M. Vinokur   +20 more
core   +3 more sources

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

175 GHz, 400-fs-pulse harmonically mode-locked surface emitting semiconductor laser [PDF]

, 2012
We report a harmonically mode-locked vertical external cavity surface emitting laser (VECSEL) producing 400 fs pulses at a repetition frequency of 175 GHz with an average output power of 300 mW.
Adrian H. Quarterman, Anne C. Tropper, Bartels, Chen, David A. Ritchie, Dupriez, Garnache, Harvey E. Beere, Hoffmann, Hoogland, Hönninger, Ian Farrer, Keith G. Wilcox, Klopp, Krainer, Lorenser, Quarterman, Quarterman, Shimizu, Sieber, Thompson, Vasilis Apostolopoulos, Wilcox, Wilcox, Wilcox, Wilcox, Yanson, Yoshida   +27 more
core   +1 more source