Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Mode Choice of Older People Before and After Shopping: A Study with London Data
Journal of Transport and Land Use, 2009 With the population aging in many countries, older people’s travel is recently getting more attention in the transportation literature. However our understanding of factors influencing their mode choice is still limited.
Fengming Su +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Transportation Mode Choice Behavior with Multinomial Logit Model: Work and School Trips
Transactions on Transport SciencesThis paper focuses on modeling transportation mode choice for commuting to work and school. The study employs a Multinomial Logit (MNL) model to examine how individuals choose their modes of transportation for work and school trips in Hawassa city ...
Yeshitila Deneke +3 more
doaj +1 more source
Why people use their cars while the built environment imposes cycling
Journal of Transport and Land Use, 2013 Residing in a high-density, diverse, and accessible neighborhood tends to be associated with less car use, more public transport, and more cycling and walking.
Veronique Van Acker +2 more
doaj +1 more source
A study on the mode choice of large-scale households' farmland transfer-in in rural China: Based on the economic analysis paradigm of transaction costs. [PDF]
PLoS One, 2023 He G, Xiao T.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
, 2018 Responses from 840 participants from the 4 largest cities in the Netherlands (Amsterdam, Den Haag, Rotterdam, Utrecht) to a survey consisting of 22 questions, of which 9 form the choice experiment.
van Arem, B. (Bart) +3 more
core +1 more source
Public Transport Accessibility and Its Effect on Mode Choice
Urban ScienceThe relationship between the service of public transport (PT) and its use is complex but can be simplified through the use of indicators. These indicators should be able to accurately reflect PT use so that improvements in the indicators lead to ...
Fabian Kühnel +3 more
doaj +1 more source