Results 191 to 200 of about 7,171,930 (396)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Commute trips in Norwegian cities: Data combining trip characteristics and revealed mode choice. [PDF]

Data Brief, 2021
Lunke EB, Fearnley N, Aarhaug J.
europepmc   +1 more source

Transport mode choice in alpine resorts in Switzerland [PDF]

, 2015
Derek Pierre Christie, Emmanuel Ravalet, Vincent Kaufmann   +2 more
openalex  

Modelling Commuters� Mode Choice: Integrating Travel Behaviour, Stated Preferences, Perception, and Socio-economic Profile [PDF]

, 2018
Puteri Paramita
openalex   +1 more source

Modelling the effects of COVID-19 on travel mode choice behaviour in India

Transportation Research Interdisciplinary Perspectives, 2020
Eeshan Bhaduri, Manoj Bs, Z. Wadud, A. Goswami, C. Choudhury   +4 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Downtown Parking Supply, Work-Trip Mode Choice and Urban Spatial Structure

, 2015
Sofia F. Franco
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Long-Term effects of COVID-19 on travel behavior in the United States: A panel study on work from home, mode choice, online shopping, and air travel. [PDF]

Transp Res Part F Traffic Psychol Behav, 2022
Javadinasr M, Maggasy T, Mohammadi M, Mohammadain K, Rahimi E, Salon D, Conway MW, Pendyala R, Derrible S.   +8 more
europepmc   +1 more source

External technology sourcing: The effect of uncertainty on governance mode choice [PDF]

This study examines the effect of external and relational uncertainty on the governance choice for inter-organizational technology sourcing. We develop a number of hypotheses about the impact of environmental turbulence, technological newness ...
Duysters, Geert, Vanhaverbeke, Wim, Vrande, Vareska van de   +2 more
core