Results 61 to 70 of about 825,318 (303)

A Hybrid Design Optimization Method using Enriched Craig-Bampton Approach [PDF]

, 2009
A hybrid design optimization method is presented which combines a number of techniques such as Component Mode Synthesis (CMS), Design of Computer Experiments and Neural Networks for surrogate modeling with Genetic Algorithms and Sequential Quadratic ...
Akcay Perdahcioglu, D., Boer, A. de, Ellenbroek, M.H.M.   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Nonlinear vibrations of large structures with uncertain parameters

Advances in Mechanical Engineering, 2017
The effects of uncertainties on the nonlinear dynamics of complex structures remain poorly mastered and most methods deal with the linear case. This article deals with a model of a large and complex structure with uncertain parameters for the nonlinear ...
Mohammed Lamrhari, Driss Sarsri, Lahcen Azrar, Miloud Rahmoune, Khalid Sbai   +4 more
doaj   +1 more source

Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. [PDF]

PLoS Pathogens, 2014
Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated K22 ...
Anna Lundin, Ronald Dijkman, Tomas Bergström, Nina Kann, Beata Adamiak, Charles Hannoun, Eveline Kindler, Hulda R Jónsdóttir, Doreen Muth, Joeri Kint, Maria Forlenza, Marcel A Müller, Christian Drosten, Volker Thiel, Edward Trybala   +14 more
doaj   +1 more source

A synthesis of logic and biology in the design of dependable systems [PDF]

, 2015
The technologies of model-based design and dependability analysis in the design of dependable systems, including software intensive systems, have advanced in recent years.
Papadopoulos, Yiannis
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Mode selection for component mode synthesis with guaranteed assembly accuracy

Journal of Sound and Vibration
In this work, a modular approach is introduced to select the most important eigenmodes for each component of a composed structural dynamics system to obtain the required accuracy of the reduced-order assembly model. To enable the use of models of complex (structural) dynamical systems in engineering practice, e.g., in a design, optimization and/or ...
Lars A.L. Janssen, Rob H.B. Fey, Bart Besselink, Nathan van de Wouw   +3 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Interval and fuzzy eigenfrequency analysis of uncertain substructured FE models

Computer Assisted Methods in Engineering and Science, 2022
This paper uses an interval and fuzzy finite element approach for the eigenfrequency analysis of a mechanical structure with uncertain parameters. The component mode synthesis method is applied for the numerical reduction of the structure, in order to ...
Hilde De Gersem, David Moens, Wim Desmet, Dirk Vandepitte   +3 more
doaj  

Identification of structural interface characteristics using component mode synthesis [PDF]

The inability to adequately model connections has limited the ability to predict overall system dynamic response. Connections between structural components are often mechanically complex and difficult to accurately model analytically. Improved analytical
Huckelbridge, A. A., Lawrence, C.
core   +1 more source