Results 101 to 110 of about 1,019,487 (291)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Experimental study of friction-induced noise generated from the printer fuser assembly (Generation mechanism and countermeasures)

Mechanical Engineering Journal
In a printer fuser assembly, unpleasant noise caused by friction-induced vibrations can occur owing to friction between the pad and the inner surface of the fixing sleeve.
Yutaka NAKANO, Katsunori CHO, Takamasa HASE, Yuki MATSUMURA, Hiroki TAKAHARA   +4 more
doaj   +1 more source

Highly efficient coupling to photonic crystal waveguides from optical fiber tapers [PDF]

, 2003
Nearly-complete mode-selective coupling from an optical fiber taper to a photonic crystal defect waveguide is demonstrated experimentally.
Barclay, Paul E., Borselli, Matthew, Painter, Oskar, Srinivasan, Kartik   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Higher-Dimensional Communications Using Multimode Fibers and Compact Components to Enable a Dense Set of Communicating Channels

Optics
Higher-dimensional communications are of interest for multiple reasons, including increasing the classical transmission capacity and, more recently, the quantum state transfer through fibers using the many modes within the fiber.
Daniel A. Nolan
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mode coupling in dynamic stabilization of MhD modes [PDF]

Plasma Physics, 1974
Existing theory of dynamic stabilization of MHD modes completely disagrees with experimental results obtained for the m=1 mode in a linear screw pinch with superimposed HF axial fields (Bz). Theory fails to describe the experimental stabilizing condition and the magnitude and structure of the dynamic force (Fexp) derived from it. There is some evidence
openaire   +3 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Transverse Mode Coupling in RHIC [PDF]

, 1990
In the Proceedings of the Workshop on the RHIC Performance, it was stated that the transverse mode coupling instability, posed a potential intensity limitation for protons. This was based on the expression I{sub b} = 4(E{sub t}/qe) Q{sub s} 4 {radical}{pi} {sigma} {ell}/(Im (Z{sub {perpendicular}}) R 3) where E{sub t} is the total energy, q the ...
openaire   +4 more sources