Results 101 to 110 of about 805,333 (299)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Construction of Motion Mode Switching System by Machine Learning for Peristaltic Mixing Conveyor Based on Intestinal Movement

IEEE Access
The high frequency of rocket launches requires low-cost solid rocket fuel. Currently, the fuel manufacturing process faces increased launch costs caused by the risk of ignition from rotary mixers and increased equipment and labor costs from batch ...
Iori Terayama, Sana Oshino, Rie Nishihama, Manabu Okui, Ryosuke Adachi, Taro Nakamura   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Measurement and Elimination of Mode Splitting: From the Perspective of the Partly Ensemble Empirical Mode Decomposition

Complexity, 2018
The problems of mode mixing, mode splitting, and pseudocomponents caused by intermittence or white noise signals during empirical mode decomposition (EMD) are difficult to resolve. The partly ensemble EMD (PEEMD) method is introduced first.
Bin Liu, Peng Zheng, Qilin Dai, Zhongli Zhou   +3 more
doaj   +1 more source

Mode mixing induced by disorder in graphene PNP junction in a magnetic field

, 2017
We study the electron transport through the graphene PNP junction under a magnetic field and show that modes mixing plays an essential role. By using the non-equilibrium Green's function method, the space distribution of the scattering state for a ...
Dai, Ning, Sun, Qing-Feng
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Nonlinear electrostatic oscillations in a cold magnetized electron-positron plasma

, 2017
We study the spatio-temporal evolution of the nonlinear electrostatic oscillations in a cold magnetized electron-positron (e-p) plasma using both analytics and simulations.
Akhiezer A. I., Birdsall C. K., Davidson R., Prabal Singh Verma, Tapan Chandra Adhyapak   +4 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Crack Detection of Turnout Straight Switch Rail Bottom Based on Nonlinear Ultrasonic Frequency Mixing Technology

Urban Rail Transit
Nonlinear ultrasonic frequency mixing exhibits high sensitivity and good localization capability for closed cracks. In this paper, nonlinear ultrasonic frequency mixing technology is used to investigate the contact acoustic nonlinearity phenomenon in ...
Chenyang Hu, Haoxiang Gao, Fengzhuang Tong, Wenbo Zhao   +3 more
doaj   +1 more source

Evidence for electron-phonon interaction in Fe$_{1-x}$M$_{x}$Sb$_{2}$ (M=Co, Cr) single crystals

, 2011
We have measured polarized Raman scattering spectra of the Fe$_{1-x}$Co$_{x}$Sb$_{2}$ and Fe$_{1-x}$Cr$_{x}$Sb$_{2}$ (0$\leq x\leq $0.5) single crystals in the temperature range between 15 K and 300 K.
C. Petrovic, M. V. Klein, N. Lazarević, Rongwei Hu, Z. Fisk, Z. V. Popović   +5 more
core   +1 more source