Results 11 to 20 of about 168,707,534 (305)

Identification of molecular toxicity pathways across early life-stages of zebrafish exposed to PCB126 using a whole transcriptomics approach

Ecotoxicology and Environmental Safety, 2021
Although withdrawn from the market in the 1980s, polychlorinated biphenyls (PCBs) are still found ubiquitously in the aquatic environment and pose a serious risk to biota due to their teratogenic potential. In fish, early life-stages are often considered
Henriette Meyer-Alert, Steve Wiseman, Song Tang, Markus Hecker, Henner Hollert   +4 more
doaj   +1 more source

Therapeutic Mode of Action of Methotrexate

Central Asian Journal of Medical Sciences, 2016
Objectives: Methotrexate (MTX) has been used in clinical practice for over a half-century and its action mechanism is believed to rely on the direct inhibition of DNA synthesis leading to suppression of cell proliferation.
Dashlkhumbe Byamba, Do-Young Kim, Chimidtseren Soodoi, Enkhtur Yadamsuren, Ariunaa Munkhbayar, Nandintsetseg Batbayar, Dashkhajidmaa Dashdondov, Oyuntsatsral Batsaikhan, Batbaatar Gunchin, Min-Geol Lee   +9 more
doaj   +1 more source

CARN Annual Conference – September 9-11, 2022

, 2022
The Collaborative Action Research Network will be holding its annual conference between September 9th and 11th, 2022 at the National University of Ireland, Maynooth.   For updates, check: https://www.carn.org.uk/events/conferences/  ...
Canadian Journal of Action Research
core   +1 more source

Mode of action of injection products

Materiales de Construccion, 1974
Not ...
H. Steinegger
doaj   +1 more source

The Mode of Action of Diuretics

, 1991
This review will address several recent findings regarding the interaction of so called loop diuretics of the furosemide type with the Na+2Cl−K+ cotransporter in the thick ascending limb of the loop of Henle (TAL): (i) The organ selectivity of these transport inhibitors is caused by their secretion by the proximal tubule leading to an increase in their
Lohrmann, E., Nitschke, R. B., Nitschke, R., Burhoff, I., Masereel, Bernard, Pirotte, Bernard, Schlatter, E., Delarge, Jacques, Lang, H. J., Englert, H. C., Salomonsson, M., Persson, A. E. G., Eidelman, O., Cabantchik, Z. I., Greger, R.   +14 more
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Mode of Action of Pesticin [PDF]

Journal of Bacteriology, 1969
The mode of action of pesticin, a bacteriocin produced by many strains ofPasturella pestis, was studied. Pesticin action on macromolecular synthesis of a sensitive strain ofEscherichia coli, strain φ, was found to have features similar to those of colicin E2-317 acting on the same strain.
M, Elgat, R, Ben-Gurion
openaire   +2 more sources

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important.
Barton, Geoffrey J, Peter J Coote, Botting, Catherine H., Katherine A Gould, Geoffrey J Barton, Hinds, Jason, Overton, Ian M., Gould, Katherine A., Coote, Peter J, Gould, Katherine A, Shirran, Sally, Botting, CH, Catherine H Botting, Barton, GJ, Coote, Peter J., Gould, KA, Shirley Graham, Botting, Catherine H, Overton, IM, Ian M Overton, Overton, Ian M, Barton, Geoffrey J., Graham, Shirley, Shirran, S, Overton, Ian M; id_orcid, Hinds, J, Sally Shirran, Coote, PJ, Jason Hinds, Barton, Geoffrey J.; id_orcid, Graham, S   +30 more
core   +1 more source

Binding proteins of destruxin A from Metarhizium against insect cell

BMC Microbiology, 2023
Destruxin A (DA) is a cyclo-hexadepsipeptidic insecticidal mycotoxin isolated from the entomopathogenic fungi, Metarhizium spp. However, its mode of action is unknown. In this study, we isolated 149 candidate DA-binding proteins by drug affinity response
Jingjing Wang, Qunfang Weng, Ke Zhang, Qiongbo Hu   +3 more
doaj   +1 more source

A Recombinant MVA-Based RSV Vaccine Induces T-Cell and Antibody Responses That Cooperate in the Protection Against RSV Infection

Frontiers in Immunology, 2022
Respiratory syncytial virus (RSV) causes a respiratory disease with a potentially fatal outcome especially in infants and elderly individuals. Several vaccines failed in pivotal clinical trials, and to date, no vaccine against RSV has been licensed.
Kathrin Endt, Yvonne Wollmann, Jana Haug, Constanze Bernig, Markus Feigl, Alexander Heiseke, Markus Kalla, Hubertus Hochrein, Mark Suter, Paul Chaplin, Ariane Volkmann   +10 more
doaj   +1 more source

The Mode of Action of Phenylindanedione [PDF]

Journal of Clinical Pathology, 1954
(P.I.D.) was an anticoagulant whicheffectively altered theone-stage prothrombin timeithasbeenusedextensively in thetreatment ofcasesofthrombosis (Blaustein, 1950;Blaustein, Shnayerson, andWallach, 1953; Dennis, Coon,Hodgson, andDuff, 1952;Toohey, 1953).
W, WALKER, R B, HUNTER
openaire   +2 more sources