Results 41 to 50 of about 168,707,534 (305)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
PYRAZOLOPYRIMIDINES AS ANTICANCER AGENTS; SYNTHESES AND MODE OF ACTION (REVIEW ARTICLE) [PDF]
Al-Azhar Journal of Pharmaceutical SciencesPyrazolopyrimidines are composed of a pyrazole ring fused with pyrimidine moiety, unlike the imidazole moiety in purines; they are initially reported as adenosine receptor antagonists.
Wafaa Zaghary +5 more
doaj +1 more source
Mode of action of fluopyram in plant-parasitic nematodes
Scientific Reports, 2022 Plant-parasitic nematodes (PPN) are responsible for severe yield losses in crop production. Management is challenging as effective and safe means are rare.
A. Sylvia S. Schleker +16 more
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Molecules, 2023 Creating new insecticide lead compounds based on the design and modification of natural products is a novel process, of which chlorfenapyr is a typical successful example.
Ping Huang +5 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Catching the mode of action [PDF]
Nature Reviews Microbiology, 2020 This study provides structural insides into the mechanism of action of mycobacterial arabinosyltransferases and the mode of action of an anti-tuberculosis drug targeting those enzymes.
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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The Mode of Action of Tyramine
Journal of Pharmacy and Pharmacology, 1963 Abstract The repeated administration of tyramine to the isolated perfused guinea-pig heart gradually decreased the positive inotropic response which was paralleled by a decrease in the noradrenaline content of the heart and an increase in the noradrenaline content of the perfusate. Phenethylamine, ephedrine, amphetamine, guanethidine and
M J, DAVEY, J B, FARMER
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source