Results 141 to 150 of about 5,793,293 (269)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Model-based design for seizure control by stimulation. [PDF]
J Neural Eng, 2020 Ashourvan A +10 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The Meta-Model Approach for Simulation-based Design Optimization.
The design of products and processes makes increasing use of computer simulations for the prediction of its performance. These computer simulations are considerably cheaper than their physical equivalent. Finding the optimal design has therefore become a
Stinstra, E.
core
Design and competitive edge: A model for design management excellence in European SME's
, 2002 This article suggests to use the conceptual model of Michael Porter Value Chain in order to integrate all the variables that explain the mechanism of value creation through design.
Borja de Mozota, B
core
A Model-Based Design Floating-Point Accumulator. Case of Study: FPGA Implementation of a Support Vector Machine Kernel Function. [PDF]
Sensors (Basel), 2020 Bassoli M, Bianchi V, De Munari I.
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
An investigation of constraint-based risk management for collaborative design
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In the context of internationally challenging economic, design has been regarded as a key factor in assisting design and manufacturing companies to survive.
Ruan, Jian
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source